Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00098198" target="_blank" >RIV/00216224:14110/17:00098198 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/17:00067377

Výsledek na webu

<a href="http://www.currentpediatrics.com/articles/reduction-of-paediatric-emergence-agitation-after-adenotonsillectomywith-nalbuphine.pdf" target="_blank" >http://www.currentpediatrics.com/articles/reduction-of-paediatric-emergence-agitation-after-adenotonsillectomywith-nalbuphine.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine

Popis výsledku v původním jazyce

Abstract Background and aim: The aim of this prospective, observational study was to evaluate the potential benefit of nalbuphine in paediatric adenotonsillectomy in comparison to alfentanil in the terms of the emergence delirium and other procedural adverse events. Methods: Monitored adverse events were tachycardia, dyspnoea, hypotension, hypertension and emergence agitation according to the adapted Watcha scale. All eligible patients were given oral premedication and general anaesthesia was induced using inhalational or intravenous route. Patients were given nalbuphine (0.1-0.2 mg.kg-1) or alfentanil (10-15 ug.kg-1) and had all requested data recorded in the study form (age, study group, metamizole usage, body weight, total dose of nalbuphine or alfentanil, ASA, studied parameters). Results: Total of 122 patients were enrolled for this study, 8 patients were excluded because of incomplete study form. This resulted in study population of 114 patients. All patients were ASA I–II. No differences in age or body weight were observed. Emergence agitation was significantly (p=0.024) more frequent in the Alfentanil group (39.66%) than in Nalbuphine group (19.64%). Tachycardia was significantly more frequent in younger patients. Dyspnoea was significantly dose-dependent and more frequent in lower dosages (p=0.045). Hypertension was more frequent in patients with higher grade of agitation, but statistically significant only in the Alfentanil group (p=0.044). Conclusion: Nalbuphine in the setting of paediatric adenotonsillectomy makes a good alternative to short acting opioid and postoperative analgesia using NSAID or other nonopioid analgesics. Our results show that nalbuphine provides less emergence agitation and therefore provides a patient better early postoperative outcome.

Název v anglickém jazyce

Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine

Popis výsledku anglicky

Abstract Background and aim: The aim of this prospective, observational study was to evaluate the potential benefit of nalbuphine in paediatric adenotonsillectomy in comparison to alfentanil in the terms of the emergence delirium and other procedural adverse events. Methods: Monitored adverse events were tachycardia, dyspnoea, hypotension, hypertension and emergence agitation according to the adapted Watcha scale. All eligible patients were given oral premedication and general anaesthesia was induced using inhalational or intravenous route. Patients were given nalbuphine (0.1-0.2 mg.kg-1) or alfentanil (10-15 ug.kg-1) and had all requested data recorded in the study form (age, study group, metamizole usage, body weight, total dose of nalbuphine or alfentanil, ASA, studied parameters). Results: Total of 122 patients were enrolled for this study, 8 patients were excluded because of incomplete study form. This resulted in study population of 114 patients. All patients were ASA I–II. No differences in age or body weight were observed. Emergence agitation was significantly (p=0.024) more frequent in the Alfentanil group (39.66%) than in Nalbuphine group (19.64%). Tachycardia was significantly more frequent in younger patients. Dyspnoea was significantly dose-dependent and more frequent in lower dosages (p=0.045). Hypertension was more frequent in patients with higher grade of agitation, but statistically significant only in the Alfentanil group (p=0.044). Conclusion: Nalbuphine in the setting of paediatric adenotonsillectomy makes a good alternative to short acting opioid and postoperative analgesia using NSAID or other nonopioid analgesics. Our results show that nalbuphine provides less emergence agitation and therefore provides a patient better early postoperative outcome.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30209 - Paediatrics

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Pediatric Research

ISSN

0971-9032

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

7

Strana od-do

490-496

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85028559348