Respiratory induced heart rate variability during slow mechanical ventilation Marker to exclude brain death patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00124678" target="_blank" >RIV/00216224:14110/17:00124678 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081731:_____/17:00480387 RIV/00159816:_____/17:00066959 RIV/62157124:16370/17:43876013

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00508-017-1176-0" target="_blank" >https://link.springer.com/article/10.1007/s00508-017-1176-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00508-017-1176-0" target="_blank" >10.1007/s00508-017-1176-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Respiratory induced heart rate variability during slow mechanical ventilation Marker to exclude brain death patients

Popis výsledku v původním jazyce

Respiratory induced heart rate variability (rHRV) was analysed in mechanically ventilated patients during two levels of sedation and brain death. Our aim was to determine whether rHRV can distinguish between different levels of sedation and especially between brain death and sedated patients. In this study 30 critically ill and 23 brain death patients were included and four respiratory rates of 15, 12, 8 and 6 breaths per minute, each lasting 5 min were used. Two sedation levels, basal and deep, were performed in the critically ill patients. Heart rate and blood pressure changes induced by ventilation were subsequently detected and analysed. Significant differences were found in rHRV and rHRV adjusted for tidal volume (rHRV/VT) between critically ill and brain death patients during slow breathing at 6 or 8 breaths per minute. The rHRV at 6 breaths per minute was below 15 ms in all brain death subjects except one. The rHRV/VT was lower than 25 ms/l at both 6 and 8 breaths per minute in all brain death patients and simultaneously at 75% of non-brain death patients was higher (specificity 1, sensitivity 0.24). Differences in rHRV and rHRV/VTs between basal and deep sedation were not significant. The main clinical benefit of the study is the finding that rHRV and rHRV/VT during 6 and 8 breaths per minute can differentiate between critically ill and brain death patients. An rHRV/VT exceeding 25 ms/l reliably excludes brain death.

Název v anglickém jazyce

Respiratory induced heart rate variability during slow mechanical ventilation Marker to exclude brain death patients

Popis výsledku anglicky

Respiratory induced heart rate variability (rHRV) was analysed in mechanically ventilated patients during two levels of sedation and brain death. Our aim was to determine whether rHRV can distinguish between different levels of sedation and especially between brain death and sedated patients. In this study 30 critically ill and 23 brain death patients were included and four respiratory rates of 15, 12, 8 and 6 breaths per minute, each lasting 5 min were used. Two sedation levels, basal and deep, were performed in the critically ill patients. Heart rate and blood pressure changes induced by ventilation were subsequently detected and analysed. Significant differences were found in rHRV and rHRV adjusted for tidal volume (rHRV/VT) between critically ill and brain death patients during slow breathing at 6 or 8 breaths per minute. The rHRV at 6 breaths per minute was below 15 ms in all brain death subjects except one. The rHRV/VT was lower than 25 ms/l at both 6 and 8 breaths per minute in all brain death patients and simultaneously at 75% of non-brain death patients was higher (specificity 1, sensitivity 0.24). Differences in rHRV and rHRV/VTs between basal and deep sedation were not significant. The main clinical benefit of the study is the finding that rHRV and rHRV/VT during 6 and 8 breaths per minute can differentiate between critically ill and brain death patients. An rHRV/VT exceeding 25 ms/l reliably excludes brain death.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

<a href="/cs/project/GAP103%2F11%2F0933" target="_blank" >GAP103/11/0933: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Wiener klinische Wochenschrift

ISSN

0043-5325

e-ISSN

1613-7671

Svazek periodika

129

Číslo periodika v rámci svazku

7-8

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

8

Strana od-do

251-258

Kód UT WoS článku

000399888100005

EID výsledku v databázi Scopus

2-s2.0-85013778471