Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00100931" target="_blank" >RIV/00216224:14110/18:00100931 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/18:00068707

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00784-017-2280-2" target="_blank" >http://dx.doi.org/10.1007/s00784-017-2280-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00784-017-2280-2" target="_blank" >10.1007/s00784-017-2280-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Popis výsledku v původním jazyce

Objectives The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children. Materials and methods This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft &gt;= 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT &gt;= 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method. Results No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions. Conclusions Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected.

Název v anglickém jazyce

Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Popis výsledku anglicky

Objectives The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children. Materials and methods This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft &gt;= 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT &gt;= 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method. Results No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions. Conclusions Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Oral Investigations

ISSN

1432-6981

e-ISSN

1436-3771

Svazek periodika

22

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

1873-1877

Kód UT WoS článku

000430387800027

EID výsledku v databázi Scopus

2-s2.0-85035151988