Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00103532" target="_blank" >RIV/00216224:14110/18:00103532 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.pscychresns.2018.08.012" target="_blank" >http://dx.doi.org/10.1016/j.pscychresns.2018.08.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pscychresns.2018.08.012" target="_blank" >10.1016/j.pscychresns.2018.08.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder

Popis výsledku v původním jazyce

Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.

Název v anglickém jazyce

Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder

Popis výsledku anglicky

Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PSYCHIATRY RESEARCH-NEUROIMAGING

ISSN

0925-4927

e-ISSN

1872-7506

Svazek periodika

280

Číslo periodika v rámci svazku

OCT 30 2018

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

56-61

Kód UT WoS článku

000443824900008

EID výsledku v databázi Scopus

2-s2.0-85052334399