Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108132" target="_blank" >RIV/00216224:14110/19:00108132 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/19:00070864

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s12975-018-0641-z" target="_blank" >http://dx.doi.org/10.1007/s12975-018-0641-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12975-018-0641-z" target="_blank" >10.1007/s12975-018-0641-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage

Popis výsledku v původním jazyce

The main objective was to evaluate, whether the subarachnoid hemorrhage (SAH)-associated early inflammatory response has focal or global character, i.e., whether areas distant to hematoma may be affected by an early inflammatory response. The second objective was to evaluate the association of anesthesia recovery time for basic reflexes/neurological functions with severity of SAH. SAH was induced in rats using an endovascular perforation model. Anesthesia recovery time was evaluated for pain reaction recovery time (spinal level), spontaneous ventilation recovery time (brain stem level), and consciousness recovery time (neocortical level). mRNA expressions of TNF, IL-1, IL-6, ICAM-1, and VCAM-1 in areas adjacent and distant to hematoma were evaluated between 2 and 8h after SAH. Serum levels of TNF, IL-1, and IL-6 were assessed at 4 and 8h after SAH. Anesthesia recovery time of all selected parameters was associated with severity of SAH. The consciousness recovery time test had the best predictive value, while the spontaneous ventilation recovery time test was able to bring information in the shortest time. The mRNA expressions of pro-inflammatory cytokines were significantly increased in severe SAH groups in both adjacent and distant areas. The inflammatory response in mild/moderate SAH groups was less strong, peaking at 4h after SAH. Serum levels of pro-inflammatory cytokines were ambiguous. Anesthesia recovery time may be useful for bleeding severity prediction in the SAH model; however, further validation is needed. Severe subarachnoid hemorrhage is associated with the strong early inflammatory response, which has a global character, while mild subarachnoid hemorrhage is accompanied by a weaker inflammation.

Název v anglickém jazyce

Early Inflammatory Response in the Brain and Anesthesia Recovery Time EvaluationAfter Experimental Subarachnoid Hemorrhage

Popis výsledku anglicky

The main objective was to evaluate, whether the subarachnoid hemorrhage (SAH)-associated early inflammatory response has focal or global character, i.e., whether areas distant to hematoma may be affected by an early inflammatory response. The second objective was to evaluate the association of anesthesia recovery time for basic reflexes/neurological functions with severity of SAH. SAH was induced in rats using an endovascular perforation model. Anesthesia recovery time was evaluated for pain reaction recovery time (spinal level), spontaneous ventilation recovery time (brain stem level), and consciousness recovery time (neocortical level). mRNA expressions of TNF, IL-1, IL-6, ICAM-1, and VCAM-1 in areas adjacent and distant to hematoma were evaluated between 2 and 8h after SAH. Serum levels of TNF, IL-1, and IL-6 were assessed at 4 and 8h after SAH. Anesthesia recovery time of all selected parameters was associated with severity of SAH. The consciousness recovery time test had the best predictive value, while the spontaneous ventilation recovery time test was able to bring information in the shortest time. The mRNA expressions of pro-inflammatory cytokines were significantly increased in severe SAH groups in both adjacent and distant areas. The inflammatory response in mild/moderate SAH groups was less strong, peaking at 4h after SAH. Serum levels of pro-inflammatory cytokines were ambiguous. Anesthesia recovery time may be useful for bleeding severity prediction in the SAH model; however, further validation is needed. Severe subarachnoid hemorrhage is associated with the strong early inflammatory response, which has a global character, while mild subarachnoid hemorrhage is accompanied by a weaker inflammation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GP14-23773P" target="_blank" >GP14-23773P: Regulace zánětlivé odpovědi prostřednictvím mikroRNA na experimaentálním modelu subarachnoidálního krvácení</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

TRANSLATIONAL STROKE RESEARCH

ISSN

1868-4483

e-ISSN

1868-601X

Svazek periodika

10

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

308-318

Kód UT WoS článku

000468375700009

EID výsledku v databázi Scopus

2-s2.0-85048831170