Transcranial magnetic stimulation in borderline personality disorder - case series

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108454" target="_blank" >RIV/00216224:14110/19:00108454 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/19:00070534

Výsledek na webu

<a href="http://dx.doi.org/10.14735/amcsnn201948" target="_blank" >http://dx.doi.org/10.14735/amcsnn201948</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn201948" target="_blank" >10.14735/amcsnn201948</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Transcranial magnetic stimulation in borderline personality disorder - case series

Popis výsledku v původním jazyce

We present the results of a case series study of individual ly navigated repetitive transcranial magnetic stimulation (rTMS) in four patients with borderline personality disorder (BPD). Patients and methods: Four patients with BPD performed a Go/NoGo task dur ing functional MRI (fMRI) designed for observ ing behavioural inhibition neural cor relates. The site within the right dorsolateral prefrontal cortex with the largest diff erence in BOLD signal between the NoGo and Go conditions was as signed as a target for rTMS in each patient. Four patients underwent 15 ses sions of individual ly navigated 10-Hz rTMS treatment at 110% of their individual rest ing motor threshold for 3 weeks (one ses sion per work ing day). One ses sion contained 1,500 pulses delivered in 15 trains by 10 s, lead ing to a total of 22,500 pulses dur ing the treatment. Results: The treatment was very well tolerated without any serious side eff ects. After the treatment, the patients reported that they felt better self-control of their emotions, especial ly anger; that their urges for self-harm and suicidal thoughts decreased or disappeared; and that their derealisation/depersonalisation episodes disappeared. Patients also showed less depres sion symp toms after the treatment. Conclusion: rTMS with neuronavigation individualised by a fMRI Go/NoGo task is a promis ing tool for reduc ing impulsive behaviour and enhanc ing emotion regulation in BPD patients. Double-blind placebo-control led studies in larger samples are neces sary to draw further conclusions about rTMS eff ectiveness in BPD.

Název v anglickém jazyce

Transcranial magnetic stimulation in borderline personality disorder - case series

Popis výsledku anglicky

We present the results of a case series study of individual ly navigated repetitive transcranial magnetic stimulation (rTMS) in four patients with borderline personality disorder (BPD). Patients and methods: Four patients with BPD performed a Go/NoGo task dur ing functional MRI (fMRI) designed for observ ing behavioural inhibition neural cor relates. The site within the right dorsolateral prefrontal cortex with the largest diff erence in BOLD signal between the NoGo and Go conditions was as signed as a target for rTMS in each patient. Four patients underwent 15 ses sions of individual ly navigated 10-Hz rTMS treatment at 110% of their individual rest ing motor threshold for 3 weeks (one ses sion per work ing day). One ses sion contained 1,500 pulses delivered in 15 trains by 10 s, lead ing to a total of 22,500 pulses dur ing the treatment. Results: The treatment was very well tolerated without any serious side eff ects. After the treatment, the patients reported that they felt better self-control of their emotions, especial ly anger; that their urges for self-harm and suicidal thoughts decreased or disappeared; and that their derealisation/depersonalisation episodes disappeared. Patients also showed less depres sion symp toms after the treatment. Conclusion: rTMS with neuronavigation individualised by a fMRI Go/NoGo task is a promis ing tool for reduc ing impulsive behaviour and enhanc ing emotion regulation in BPD patients. Double-blind placebo-control led studies in larger samples are neces sary to draw further conclusions about rTMS eff ectiveness in BPD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

1802-4041

Svazek periodika

82

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

48-52

Kód UT WoS článku

000458015800006

EID výsledku v databázi Scopus

2-s2.0-85066980359