MicroRNA analysis in multiple myeloma and extramedullary disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108621" target="_blank" >RIV/00216224:14110/19:00108621 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clml.2019.09.103" target="_blank" >http://dx.doi.org/10.1016/j.clml.2019.09.103</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clml.2019.09.103" target="_blank" >10.1016/j.clml.2019.09.103</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNA analysis in multiple myeloma and extramedullary disease

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are short non-coding RNA molecules that are involved in many physiological and pathological processes. Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells (PCs). Survival of patients is negatively affected by extramedullary disease (EM). EM occurs when PCs migrate out of the bone marrow (BM) and lose the dependence to its microenvironment. The mechanism by which the EM occurs is not yet elucidated. The importance of miRNA in the pathogenesis of MM has been demonstrated by several studies. We assume that they are involved in the development of EM. Aims: The aim of this work was to analyze different expression of miRNA in BM PCs of EM vs MM patients.

Název v anglickém jazyce

MicroRNA analysis in multiple myeloma and extramedullary disease

Popis výsledku anglicky

MicroRNAs (miRNAs) are short non-coding RNA molecules that are involved in many physiological and pathological processes. Multiple myeloma (MM) is the second most common hematological malignancy of plasma cells (PCs). Survival of patients is negatively affected by extramedullary disease (EM). EM occurs when PCs migrate out of the bone marrow (BM) and lose the dependence to its microenvironment. The mechanism by which the EM occurs is not yet elucidated. The importance of miRNA in the pathogenesis of MM has been demonstrated by several studies. We assume that they are involved in the development of EM. Aims: The aim of this work was to analyze different expression of miRNA in BM PCs of EM vs MM patients.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NV17-29343A" target="_blank" >NV17-29343A: Analýza mikroprostředí kostní dřeně u extramedulárního relapsu mnohočetného myelomu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů