Beat-to-beat variability of pulse wave velocity

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Beat-to-beat variability of pulse wave velocity

Popis výsledku v původním jazyce

Pulse wave velocity (PWV) increase is a marker of decreased arterial compliance (C). C decreases with increased blood pressure (BP), due to endothelial dysfunction and structural changes of the arterial wall. Increased mean PWV is observed in diabetics as well as in hypertonics. Mean PWV was analysed in many studies, but beat-to-beat changes of the PWV were less described. Aim of this pilot study is analysis of PWV beat-to-beat variability in dependence of body position. PWV was measured in II. type diabetics (DM: 7m/8f, age 68±10 years, BP 158/90±19/9 mmHg) and healthy controls (Con: 5m/6f, age 23±2 years, BP 117/76±9/5 mmHg). PWV was recorded by method based on multichannel full body bioimpedance. Protocol consisted of 6 min of supine (sup) and 6 min of head up tilt in 45°(hut). PWV of left forearm (PWVlf) and left calf (PWVlc) were measured. Variability was counted as mean power spectra of PWV in frequency bands LF (0.04 – 0.15 Hz) and HF (0.15 – 0.5 Hz). Results: LF-PWVlf, HF-PWVlf and HF-PWVlc in sup were higher in DM than in Con. During hut LF-PWVlc and HF-PWVlc increased in both groups; LF-PWVlf and HF-PWVlf increased only in Con. During hut of DM, PWVlf was lower than PWVlc. Decreased ability of arterial wall to dampen blood pressure changes probably could lead to higher PWV variability. This could be caused by hypertension and changed arterial stiffness (differences between groups), or by blood redistribution during body position change (differences between sup/hut and lf/cl). This pilot study showed, that PWV variability was changed by health condition, body position and measured artery position. Clear understanding of mechanism influencing PWV variability requires further study.

Název v anglickém jazyce

Beat-to-beat variability of pulse wave velocity

Popis výsledku anglicky

Pulse wave velocity (PWV) increase is a marker of decreased arterial compliance (C). C decreases with increased blood pressure (BP), due to endothelial dysfunction and structural changes of the arterial wall. Increased mean PWV is observed in diabetics as well as in hypertonics. Mean PWV was analysed in many studies, but beat-to-beat changes of the PWV were less described. Aim of this pilot study is analysis of PWV beat-to-beat variability in dependence of body position. PWV was measured in II. type diabetics (DM: 7m/8f, age 68±10 years, BP 158/90±19/9 mmHg) and healthy controls (Con: 5m/6f, age 23±2 years, BP 117/76±9/5 mmHg). PWV was recorded by method based on multichannel full body bioimpedance. Protocol consisted of 6 min of supine (sup) and 6 min of head up tilt in 45°(hut). PWV of left forearm (PWVlf) and left calf (PWVlc) were measured. Variability was counted as mean power spectra of PWV in frequency bands LF (0.04 – 0.15 Hz) and HF (0.15 – 0.5 Hz). Results: LF-PWVlf, HF-PWVlf and HF-PWVlc in sup were higher in DM than in Con. During hut LF-PWVlc and HF-PWVlc increased in both groups; LF-PWVlf and HF-PWVlf increased only in Con. During hut of DM, PWVlf was lower than PWVlc. Decreased ability of arterial wall to dampen blood pressure changes probably could lead to higher PWV variability. This could be caused by hypertension and changed arterial stiffness (differences between groups), or by blood redistribution during body position change (differences between sup/hut and lf/cl). This pilot study showed, that PWV variability was changed by health condition, body position and measured artery position. Clear understanding of mechanism influencing PWV variability requires further study.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů