Type 2 diabetes genetic risk score and morbidity and mortality associated with diabetic kidney disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00120125" target="_blank" >RIV/00216224:14110/19:00120125 - isvavai.cz</a>
Výsledek na webu
<a href="https://link.springer.com/article/10.1007/s00125-019-4946-6" target="_blank" >https://link.springer.com/article/10.1007/s00125-019-4946-6</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Type 2 diabetes genetic risk score and morbidity and mortality associated with diabetic kidney disease
Popis výsledku v původním jazyce
Diabetic kidney disease (DKD) is one of the most serious complications of type 2 diabetes mellitus (T2DM). Individual predisposition to development and progression of DKD has well established genetic component however it is still insufficiently explored. Genetic predisposition to T2DM is comprehensively described and genetic risk score (GRS) composed of 65 SNPs that is associated with 3-times higher risk of T2DM development has been established. In our study we tested the hypothesis that reduced GRS (comprised of 21 SNP with highest OR) might represent a risk factor for DKD progression and cardiovascular morbidity and mortality in T2DM patients in the Czech population.
Název v anglickém jazyce
Type 2 diabetes genetic risk score and morbidity and mortality associated with diabetic kidney disease
Popis výsledku anglicky
Diabetic kidney disease (DKD) is one of the most serious complications of type 2 diabetes mellitus (T2DM). Individual predisposition to development and progression of DKD has well established genetic component however it is still insufficiently explored. Genetic predisposition to T2DM is comprehensively described and genetic risk score (GRS) composed of 65 SNPs that is associated with 3-times higher risk of T2DM development has been established. In our study we tested the hypothesis that reduced GRS (comprised of 21 SNP with highest OR) might represent a risk factor for DKD progression and cardiovascular morbidity and mortality in T2DM patients in the Czech population.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30202 - Endocrinology and metabolism (including diabetes, hormones)
Návaznosti výsledku
Projekt
<a href="/cs/project/NV18-01-00046" target="_blank" >NV18-01-00046: Genetické skóre v predikci rizika diabetu a jeho komplikací</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů