Relationship between genetic risk score for kidney function and diabetic kidney disease progression
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00120129" target="_blank" >RIV/00216224:14110/20:00120129 - isvavai.cz</a>
Výsledek na webu
<a href="https://link.springer.com/article/10.1007/s00125-020-05221-5" target="_blank" >https://link.springer.com/article/10.1007/s00125-020-05221-5</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Relationship between genetic risk score for kidney function and diabetic kidney disease progression
Popis výsledku v původním jazyce
Background and aims: Diabetic kidney disease (DKD) is a serious diabetic complication. Several risk factors contribute to the DKD development or progression (e.g. glucose control, hypertension, dyslipidaemia). Genetic predisposition also contributes to the total risk however it is still insufficiently explored. Recently, several genome-wide association studies (GWAS) identified a number of single nucleotide polymorphisms (SNP) associated with kidney function. We selected 9 SNPs and constructed a genetic risk score (GRS). The aim of the work was to find out whether GRS can predict the progression of DKD or cardiovascular morbidity and mortality in patients with T2DM in the Czech population.
Název v anglickém jazyce
Relationship between genetic risk score for kidney function and diabetic kidney disease progression
Popis výsledku anglicky
Background and aims: Diabetic kidney disease (DKD) is a serious diabetic complication. Several risk factors contribute to the DKD development or progression (e.g. glucose control, hypertension, dyslipidaemia). Genetic predisposition also contributes to the total risk however it is still insufficiently explored. Recently, several genome-wide association studies (GWAS) identified a number of single nucleotide polymorphisms (SNP) associated with kidney function. We selected 9 SNPs and constructed a genetic risk score (GRS). The aim of the work was to find out whether GRS can predict the progression of DKD or cardiovascular morbidity and mortality in patients with T2DM in the Czech population.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30202 - Endocrinology and metabolism (including diabetes, hormones)
Návaznosti výsledku
Projekt
<a href="/cs/project/NV18-01-00046" target="_blank" >NV18-01-00046: Genetické skóre v predikci rizika diabetu a jeho komplikací</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů