Increasing procoagulant activity of circulating microparticles in patients living with HIV

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00115216" target="_blank" >RIV/00216224:14110/20:00115216 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00073095

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.medmal.2019.09.013" target="_blank" >http://dx.doi.org/10.1016/j.medmal.2019.09.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.medmal.2019.09.013" target="_blank" >10.1016/j.medmal.2019.09.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increasing procoagulant activity of circulating microparticles in patients living with HIV

Popis výsledku v původním jazyce

Objectives Individuals with HIV have a higher risk for non-AIDS diseases associated with procoagulant status. Microparticles are elevated in disorders that are associated with thrombosis (e.g. cardiovascular disease). We investigated the association between microparticle levels in untreated and treated subjects with HIV, and determined the dependence on immune status, viral replication, and duration of antiretroviral therapy. Patients and methods The study was conducted among 144 subjects with HIV, including 123 subjects on antiretroviral therapy and 21 subjects before the initiation of treatment. A control group of 40 healthy HIV-negative adults matched for age and sex was used for comparisons of microparticle levels. Subjects on treatment were divided into five groups depending on the period of antiretroviral exposure. Statistically significant differences were determined by the Kruskal-Wallis test and ML chi-square test. The relationship of microparticles with other parameters was analyzed by Spearman’s coefficient of correlation. Results Microparticle levels were significantly higher in subjects with HIV without treatment and on treatment compared with HIV-negative controls (P &lt; 0.001). The amount of microparticles was similar between the groups on treatment (P = 0.913). No association between microparticle level and CD4+ count, CD4+/CD8+ ratio, number of HIV-1 RNA copies or duration of exposure to antiretroviral treatment was found. Conclusions Increased levels of microparticles might occur by processes independent of viral replication and CD4+ cell count, and microparticle release might persist even during viral suppression by antiretroviral treatment. Elevated microparticle levels might occur in response to other triggers.

Název v anglickém jazyce

Increasing procoagulant activity of circulating microparticles in patients living with HIV

Popis výsledku anglicky

Objectives Individuals with HIV have a higher risk for non-AIDS diseases associated with procoagulant status. Microparticles are elevated in disorders that are associated with thrombosis (e.g. cardiovascular disease). We investigated the association between microparticle levels in untreated and treated subjects with HIV, and determined the dependence on immune status, viral replication, and duration of antiretroviral therapy. Patients and methods The study was conducted among 144 subjects with HIV, including 123 subjects on antiretroviral therapy and 21 subjects before the initiation of treatment. A control group of 40 healthy HIV-negative adults matched for age and sex was used for comparisons of microparticle levels. Subjects on treatment were divided into five groups depending on the period of antiretroviral exposure. Statistically significant differences were determined by the Kruskal-Wallis test and ML chi-square test. The relationship of microparticles with other parameters was analyzed by Spearman’s coefficient of correlation. Results Microparticle levels were significantly higher in subjects with HIV without treatment and on treatment compared with HIV-negative controls (P &lt; 0.001). The amount of microparticles was similar between the groups on treatment (P = 0.913). No association between microparticle level and CD4+ count, CD4+/CD8+ ratio, number of HIV-1 RNA copies or duration of exposure to antiretroviral treatment was found. Conclusions Increased levels of microparticles might occur by processes independent of viral replication and CD4+ cell count, and microparticle release might persist even during viral suppression by antiretroviral treatment. Elevated microparticle levels might occur in response to other triggers.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30230 - Other clinical medicine subjects

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Médecine et maladies infectiuses

ISSN

0399-077X

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

7

Strana od-do

555-561

Kód UT WoS článku

000574243600003

EID výsledku v databázi Scopus

2-s2.0-85073259907