Antioxidants in patients living with HIV on antiretrovirals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074617" target="_blank" >RIV/65269705:_____/21:00074617 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/21:00557426 RIV/00216224:14110/21:00123033

Výsledek na webu

<a href="https://mmsl.cz/artkey/mms-202102-0001_antioxidants-in-patients-living-with-hiv-on-antiretrovirals.php" target="_blank" >https://mmsl.cz/artkey/mms-202102-0001_antioxidants-in-patients-living-with-hiv-on-antiretrovirals.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.31482/mmsl.2021.005" target="_blank" >10.31482/mmsl.2021.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antioxidants in patients living with HIV on antiretrovirals

Popis výsledku v původním jazyce

Oxidative stress is considered predictors of diseases associated with aging (cardiovascular disease, neurodegenerative disease, malignancies, and others) in HIV-negative general population. Antioxidants were investigated in people living with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Clinical studies in this population are controversial. Methods The study was conducted among 213 subjects with HIV, including 172 subjects on antiretro-virals and 41 subjects before the initiation of treatment. The control group consisted of healthy HIV-negative adults. We compared the reduced glutathione and ferric reducing antioxidant power levels in HIV untreated and treated patients and controls. Significant differences were determined by appropriate statistical tests (t-test, Mann-Whitney U test, Kolmogorov-Smirnov test, ANOVA, Kruskal-Wallis test). Relationships between continuous variables were quantified using Spearman&apos;s rank correlation coefficient. Results Glutathione levels were significantly lower in the treated group compared with the untreated group and controls (P &lt; 0.001). Differences in total antioxidant levels between groups were not found. Conclusions Significant decrease of antioxidants was found independent of the virologic status of HIV patients on antiretroviral treatment. Persistence of these abnormal parameters may contribute and predispose to the premature development of diseases associated with aging.

Název v anglickém jazyce

Antioxidants in patients living with HIV on antiretrovirals

Popis výsledku anglicky

Oxidative stress is considered predictors of diseases associated with aging (cardiovascular disease, neurodegenerative disease, malignancies, and others) in HIV-negative general population. Antioxidants were investigated in people living with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Clinical studies in this population are controversial. Methods The study was conducted among 213 subjects with HIV, including 172 subjects on antiretro-virals and 41 subjects before the initiation of treatment. The control group consisted of healthy HIV-negative adults. We compared the reduced glutathione and ferric reducing antioxidant power levels in HIV untreated and treated patients and controls. Significant differences were determined by appropriate statistical tests (t-test, Mann-Whitney U test, Kolmogorov-Smirnov test, ANOVA, Kruskal-Wallis test). Relationships between continuous variables were quantified using Spearman&apos;s rank correlation coefficient. Results Glutathione levels were significantly lower in the treated group compared with the untreated group and controls (P &lt; 0.001). Differences in total antioxidant levels between groups were not found. Conclusions Significant decrease of antioxidants was found independent of the virologic status of HIV patients on antiretroviral treatment. Persistence of these abnormal parameters may contribute and predispose to the premature development of diseases associated with aging.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vojenské zdravotnické listy

ISSN

0372-7025

e-ISSN

—

Svazek periodika

90

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

54-60

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85108181784