Non-coding RNAs and Cardiac Arrhythmias

Kód výsledku v IS VaVaI

RIV/00216224:14110/20:00115272 - isvavai.cz

Výsledek na webu

https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17

DOI - Digital Object Identifier

10.1007/978-981-15-1671-9_17

Jazyk výsledku

angličtina

Název v původním jazyce

Non-coding RNAs and Cardiac Arrhythmias

Popis výsledku v původním jazyce

Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Název v anglickém jazyce

Non-coding RNAs and Cardiac Arrhythmias

Popis výsledku anglicky

Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

LQ1601: CEITEC 2020

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advances in Experimental Medicine and Biology

ISSN

0065-2598

e-ISSN

2214-8019

Svazek periodika

1229

Číslo periodika v rámci svazku

2020

Stát vydavatele periodika

SG - Singapurská republika

Počet stran výsledku

14

Strana od-do

287-300

Kód UT WoS článku

000539026500017

EID výsledku v databázi Scopus

2-s2.0-85083378686