Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00115781" target="_blank" >RIV/00216224:14110/20:00115781 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00072672

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-020-61264-z.pdf" target="_blank" >https://www.nature.com/articles/s41598-020-61264-z.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-020-61264-z" target="_blank" >10.1038/s41598-020-61264-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

Popis výsledku v původním jazyce

The cortico-striatal-pallidal-thalamic and limbic circuits are suggested to play a crucial role in the pathophysiology of depression. Stimulation of deep brain targets might improve symptoms in treatment-resistant depression. However, a better understanding of connectivity properties of deep brain structures potentially implicated in deep brain stimulation (DBS) treatment is needed. Using high-density EEG, we explored the directed functional connectivity at rest in 25 healthy subjects and 26 patients with moderate to severe depression within the bipolar affective disorder, depressive episode, and recurrent depressive disorder. We computed the Partial Directed Coherence on the source EEG signals focusing on the amygdala, anterior cingulate, putamen, pallidum, caudate, and thalamus. The global efficiency for the whole brain and the local efficiency, clustering coefficient, outflow, and strength for the selected structures were calculated. In the right amygdala, all the network metrics were significantly higher (p &lt; 0.001) in patients than in controls. The global efficiency was significantly higher (p &lt; 0.05) in patients than in controls, showed no correlation with status of depression, but decreased with increasing medication intake (R-2 = 0.59 and p = 1.52e-05). The amygdala seems to play an important role in neurobiology of depression. Practical treatment studies would be necessary to assess the amygdala as a potential future DBS target for treating depression.

Název v anglickém jazyce

Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

Popis výsledku anglicky

The cortico-striatal-pallidal-thalamic and limbic circuits are suggested to play a crucial role in the pathophysiology of depression. Stimulation of deep brain targets might improve symptoms in treatment-resistant depression. However, a better understanding of connectivity properties of deep brain structures potentially implicated in deep brain stimulation (DBS) treatment is needed. Using high-density EEG, we explored the directed functional connectivity at rest in 25 healthy subjects and 26 patients with moderate to severe depression within the bipolar affective disorder, depressive episode, and recurrent depressive disorder. We computed the Partial Directed Coherence on the source EEG signals focusing on the amygdala, anterior cingulate, putamen, pallidum, caudate, and thalamus. The global efficiency for the whole brain and the local efficiency, clustering coefficient, outflow, and strength for the selected structures were calculated. In the right amygdala, all the network metrics were significantly higher (p &lt; 0.001) in patients than in controls. The global efficiency was significantly higher (p &lt; 0.05) in patients than in controls, showed no correlation with status of depression, but decreased with increasing medication intake (R-2 = 0.59 and p = 1.52e-05). The amygdala seems to play an important role in neurobiology of depression. Practical treatment studies would be necessary to assess the amygdala as a potential future DBS target for treating depression.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

000537496200001

EID výsledku v databázi Scopus

2-s2.0-85081579844