Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00119502" target="_blank" >RIV/00216224:14740/21:00119502 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081731:_____/21:00544467 RIV/00159816:_____/21:00074743

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/epi.16883" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/epi.16883</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/epi.16883" target="_blank" >10.1111/epi.16883</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus

Popis výsledku v původním jazyce

We hypothesized that local/regional properties of stimulated structure/circuitry contribute to the effect of deep brain stimulation (DBS). We analyzed intracerebral electroencephalographic (EEG) recordings from externalized DBS electrodes targeted bilaterally in the anterior nuclei of the thalamus (ANT) in 12 patients (six responders, six nonresponders) with more than 1 year of follow-up care. In the bipolar local field potentials of the EEG, spectral power (PW) and power spectral entropy (PSE) were calculated in the passbands 1-4, 4-8, 8-12, 12-20, 20-45, 65-80, 80-200 and 200-500 Hz. The most significant differences between responders and nonresponders were observed in the BRIDGE area (bipolar recordings with one contact within the ANT and the second contact in adjacent tissue). In responders, PW was significantly decreased in the frequency bands of 65-80, 80-200, and 200-500 Hz (p &lt; .05); PSE was significantly increased in all frequency bands (p &lt; .05) except for 200-500 Hz (p = .06). The local EEG characteristics of ANT recorded after implantation may play a significant role in DBS response prediction.

Název v anglickém jazyce

Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus

Popis výsledku anglicky

We hypothesized that local/regional properties of stimulated structure/circuitry contribute to the effect of deep brain stimulation (DBS). We analyzed intracerebral electroencephalographic (EEG) recordings from externalized DBS electrodes targeted bilaterally in the anterior nuclei of the thalamus (ANT) in 12 patients (six responders, six nonresponders) with more than 1 year of follow-up care. In the bipolar local field potentials of the EEG, spectral power (PW) and power spectral entropy (PSE) were calculated in the passbands 1-4, 4-8, 8-12, 12-20, 20-45, 65-80, 80-200 and 200-500 Hz. The most significant differences between responders and nonresponders were observed in the BRIDGE area (bipolar recordings with one contact within the ANT and the second contact in adjacent tissue). In responders, PW was significantly decreased in the frequency bands of 65-80, 80-200, and 200-500 Hz (p &lt; .05); PSE was significantly increased in all frequency bands (p &lt; .05) except for 200-500 Hz (p = .06). The local EEG characteristics of ANT recorded after implantation may play a significant role in DBS response prediction.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/GA21-25953S" target="_blank" >GA21-25953S: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epilepsia

ISSN

0013-9580

e-ISSN

—

Svazek periodika

62

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

„E70“-„E75“

Kód UT WoS článku

000631593800001

EID výsledku v databázi Scopus

2-s2.0-85102899032