Physiologic heart rate dependency of the PQ interval and its sex differences

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00116357" target="_blank" >RIV/00216224:14110/20:00116357 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00072749

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-020-59480-8" target="_blank" >https://www.nature.com/articles/s41598-020-59480-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-020-59480-8" target="_blank" >10.1038/s41598-020-59480-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Physiologic heart rate dependency of the PQ interval and its sex differences

Popis výsledku v původním jazyce

On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studied PQ heart rate dependency in 599 healthy subjects (aged 33.5 +/- 9.3 years, 288 females) in whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 ECG samples were selected (1256 +/- 244 per subject) to measure PQ and QT intervals and P wave durations. For each measured ECG sample, 5-minute history of preceding cardiac cycles was also obtained. Although less rate dependent than the QT intervals (36 +/- 19% of linear slopes), PQ intervals were found to be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significantly more curved in females compared to males. The PQ interval also responded to the heart rate changes with a delay which was highly sex dependent (95% adaptation in females and males after 114.9 +/- 81.1 vs 65.4 +/- 64.3 seconds, respectively, p &lt; 0.00001). P wave duration was even less rate dependent than the PQ interval (9 +/- 10% of linear QT/RR slopes). Rate corrected P wave duration was marginally but significantly shorter in females than in males (106.8 +/- 8.4 vs 110.2 +/- 7.9 ms, p &lt; 0.00001). In addition to establishing physiologic standards, the study suggests that the curvatures and adaptation delay of the PQ/cycle-length dependency should be included in future non-invasive studies of atrial depolarizations.

Název v anglickém jazyce

Physiologic heart rate dependency of the PQ interval and its sex differences

Popis výsledku anglicky

On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studied PQ heart rate dependency in 599 healthy subjects (aged 33.5 +/- 9.3 years, 288 females) in whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 ECG samples were selected (1256 +/- 244 per subject) to measure PQ and QT intervals and P wave durations. For each measured ECG sample, 5-minute history of preceding cardiac cycles was also obtained. Although less rate dependent than the QT intervals (36 +/- 19% of linear slopes), PQ intervals were found to be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significantly more curved in females compared to males. The PQ interval also responded to the heart rate changes with a delay which was highly sex dependent (95% adaptation in females and males after 114.9 +/- 81.1 vs 65.4 +/- 64.3 seconds, respectively, p &lt; 0.00001). P wave duration was even less rate dependent than the PQ interval (9 +/- 10% of linear QT/RR slopes). Rate corrected P wave duration was marginally but significantly shorter in females than in males (106.8 +/- 8.4 vs 110.2 +/- 7.9 ms, p &lt; 0.00001). In addition to establishing physiologic standards, the study suggests that the curvatures and adaptation delay of the PQ/cycle-length dependency should be included in future non-invasive studies of atrial depolarizations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

1-17

Kód UT WoS článku

000562888500027

EID výsledku v databázi Scopus

2-s2.0-85079334687