Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F13%3A00421200" target="_blank" >RIV/68081731:_____/13:00421200 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects

Popis výsledku v původním jazyce

The dependency of the QT interval to the previous RR intervals has been widely studied, QT/RR slope and other modeling techniques revealed individual-specific relationship. In this work we studied the relationship between QT/RR slope and a basal QTc interval in 154 healthy subjects and in 97 patients with the inherited long QT syndrome type-1 (LQT1) to provide insights into the effect of the impairment of the outwardly directed delayed rectifier potassium current on the dynamic QT-RR coupling. QT/RR slope values show strong relationship to basal QTc interval in healthy (R=0.65; p<0.00001) and in LQT1 patients (R=0.56; p<0.00001). The dependency of QT/RR slope on QTc is steeper in healthy (a1=0.0016 0.0002) than in LQT1 (a1=0.0010 0.0002), p<0.0001. Thesteeper dependency on QTc in healthy preserves proper shortening of QT intervals during increased heart rate in healthy while in LQT1 patients the QT intervals does not adapt to increased heart rate sufficiently (lack of QT adaptation to

Název v anglickém jazyce

Comparing the Relationship between QT/RR Slope and Basal QTc in LQT1 Patients and Healthy Subjects

Popis výsledku anglicky

The dependency of the QT interval to the previous RR intervals has been widely studied, QT/RR slope and other modeling techniques revealed individual-specific relationship. In this work we studied the relationship between QT/RR slope and a basal QTc interval in 154 healthy subjects and in 97 patients with the inherited long QT syndrome type-1 (LQT1) to provide insights into the effect of the impairment of the outwardly directed delayed rectifier potassium current on the dynamic QT-RR coupling. QT/RR slope values show strong relationship to basal QTc interval in healthy (R=0.65; p<0.00001) and in LQT1 patients (R=0.56; p<0.00001). The dependency of QT/RR slope on QTc is steeper in healthy (a1=0.0016 0.0002) than in LQT1 (a1=0.0010 0.0002), p<0.0001. Thesteeper dependency on QTc in healthy preserves proper shortening of QT intervals during increased heart rate in healthy while in LQT1 patients the QT intervals does not adapt to increased heart rate sufficiently (lack of QT adaptation to

Druh

D - Stať ve sborníku

CEP obor

JA - Elektronika a optoelektronika, elektrotechnika

OECD FORD obor

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Projekt

<a href="/cs/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology /40./

ISBN

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ISSN

2325-8861

e-ISSN

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Počet stran výsledku

4

Strana od-do

65-68

Název nakladatele

Computing in Cardiology

Místo vydání

Zaragoza

Místo konání akce

Zaragoza

Datum konání akce

22. 9. 2013

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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