Quality control of clinical-grade human embryonic stem cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F23%3A00134631" target="_blank" >RIV/00216224:14110/23:00134631 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Quality control of clinical-grade human embryonic stem cells

Popis výsledku v původním jazyce

Human embryonic stem cells are able to differentiate into every cell type in the human body making them a tremendous cell source for regenerative medicine. However, the production of human embryonic stem cell lines for clinical use is challenging as clean rooms, highly-qualified personnel, and standard operating procedures for both manufacture and quality control are required. Here we present the quality control of clinical-grade hESC lines that were derived in xeno-free, feeder-free conditions, and according to current good manufacturing practices. In-depth quality control provides essential information about the safety, pluripotency, and differentiation potential of lines and it is a necessary component of new clinical-grade hESC line establishment.

Název v anglickém jazyce

Quality control of clinical-grade human embryonic stem cells

Popis výsledku anglicky

Human embryonic stem cells are able to differentiate into every cell type in the human body making them a tremendous cell source for regenerative medicine. However, the production of human embryonic stem cell lines for clinical use is challenging as clean rooms, highly-qualified personnel, and standard operating procedures for both manufacture and quality control are required. Here we present the quality control of clinical-grade hESC lines that were derived in xeno-free, feeder-free conditions, and according to current good manufacturing practices. In-depth quality control provides essential information about the safety, pluripotency, and differentiation potential of lines and it is a necessary component of new clinical-grade hESC line establishment.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

<a href="/cs/project/NU22-08-00629" target="_blank" >NU22-08-00629: Vývoj postupů pro léčbu makulární degenerace sítnice deriváty lidských pluripotentních kmenových buněk</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů