Protein cargo in extracellular vesicles as the key mediator in the progression of cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00135931" target="_blank" >RIV/00216224:14110/24:00135931 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10474323

Výsledek na webu

<a href="https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01408-6" target="_blank" >https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01408-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12964-023-01408-6" target="_blank" >10.1186/s12964-023-01408-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Protein cargo in extracellular vesicles as the key mediator in the progression of cancer

Popis výsledku v původním jazyce

Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient cells. Tumour-derived exosomes (TDEs) participate in many important molecular pathways and affect various hallmarks of cancer, including fibroblasts activation, modification of the tumour microenvironment (TME), modulation of immune responses, angiogenesis promotion, setting the pre-metastatic niche, enhancing metastatic potential, and affecting therapy sensitivity and resistance. The unique exosome biogenesis, composition, nontoxicity, and ability to target specific tumour cells bring up their use as promising drug carriers and cancer biomarkers. In this review, we focus on the role of exosomes, with an emphasis on their protein cargo, in the key mechanisms promoting cancer progression. We also briefly summarise the mechanism of exosome biogenesis, its structure, protein composition, and potential as a signalling hub in both normal and pathological conditions.A1Dxc4hLEvJAjvXsZVsCuzVideo Abstract

Název v anglickém jazyce

Protein cargo in extracellular vesicles as the key mediator in the progression of cancer

Popis výsledku anglicky

Exosomes are small vesicles of endosomal origin that are released by almost all cell types, even those that are pathologically altered. Exosomes widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient cells. Tumour-derived exosomes (TDEs) participate in many important molecular pathways and affect various hallmarks of cancer, including fibroblasts activation, modification of the tumour microenvironment (TME), modulation of immune responses, angiogenesis promotion, setting the pre-metastatic niche, enhancing metastatic potential, and affecting therapy sensitivity and resistance. The unique exosome biogenesis, composition, nontoxicity, and ability to target specific tumour cells bring up their use as promising drug carriers and cancer biomarkers. In this review, we focus on the role of exosomes, with an emphasis on their protein cargo, in the key mechanisms promoting cancer progression. We also briefly summarise the mechanism of exosome biogenesis, its structure, protein composition, and potential as a signalling hub in both normal and pathological conditions.A1Dxc4hLEvJAjvXsZVsCuzVideo Abstract

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cell Communication and Signaling

ISSN

1478-811X

e-ISSN

1478-811X

Svazek periodika

22

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

20

Strana od-do

1-20

Kód UT WoS článku

001140012200001

EID výsledku v databázi Scopus

2-s2.0-85181870292