Periprosthetic inflammation: From the cellular level to clinical implications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00142267" target="_blank" >RIV/00216224:14110/25:00142267 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/jbmrplus/advance-article/doi/10.1093/jbmrpl/ziaf154/8257522" target="_blank" >https://academic.oup.com/jbmrplus/advance-article/doi/10.1093/jbmrpl/ziaf154/8257522</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jbmrpl/ziaf154" target="_blank" >10.1093/jbmrpl/ziaf154</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Periprosthetic inflammation: From the cellular level to clinical implications

Popis výsledku v původním jazyce

Periprosthetic inflammation is a crucial factor contributing to aseptic loosening, the leading cause of implant failures. Metallic debris, including nanoparticles, sub-micron particles, and ions, plays a central role in triggering inflammatory responses around orthopaedic implants. Exposure to the debris activates macrophages via Toll-like receptors (TLRs) and NOD-like receptors (NLRs), which in turn leads to the production of pro-inflammatory cytokines. This signalling cascade subsequently drives osteoclast activation, resulting in periprosthetic bone loss and, ultimately, implant loosening. Recent research has focused on strategies to prevent aseptic loosening by targeting the inflammation induced by metallic particles/ions. Pharmacological interventions aimed at modulating macrophage activation and inhibiting specific inflammatory pathways have shown promise in reducing osteoclast activity and excessive bone resorption. This review provides a comprehensive overview of the processes involved in the pathogenesis of periprosthetic inflammation, beginning with the release of metallic debris and its recognition by immune cells, followed by the inflammatory reactions that lead to osteoclastogenesis and bone loss. A detailed understanding of these molecular mechanisms is essential for the development of targeted approaches to prevent aseptic loosening, improve long-term patient outcomes, and alleviate the economic burden on healthcare systems.

Název v anglickém jazyce

Periprosthetic inflammation: From the cellular level to clinical implications

Popis výsledku anglicky

Periprosthetic inflammation is a crucial factor contributing to aseptic loosening, the leading cause of implant failures. Metallic debris, including nanoparticles, sub-micron particles, and ions, plays a central role in triggering inflammatory responses around orthopaedic implants. Exposure to the debris activates macrophages via Toll-like receptors (TLRs) and NOD-like receptors (NLRs), which in turn leads to the production of pro-inflammatory cytokines. This signalling cascade subsequently drives osteoclast activation, resulting in periprosthetic bone loss and, ultimately, implant loosening. Recent research has focused on strategies to prevent aseptic loosening by targeting the inflammation induced by metallic particles/ions. Pharmacological interventions aimed at modulating macrophage activation and inhibiting specific inflammatory pathways have shown promise in reducing osteoclast activity and excessive bone resorption. This review provides a comprehensive overview of the processes involved in the pathogenesis of periprosthetic inflammation, beginning with the release of metallic debris and its recognition by immune cells, followed by the inflammatory reactions that lead to osteoclastogenesis and bone loss. A detailed understanding of these molecular mechanisms is essential for the development of targeted approaches to prevent aseptic loosening, improve long-term patient outcomes, and alleviate the economic burden on healthcare systems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30211 - Orthopaedics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JBMR PLUS

ISSN

2473-4039

e-ISSN

2473-4039

Svazek periodika

9

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

001593825900001

EID výsledku v databázi Scopus

2-s2.0-105019528592