Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00144445" target="_blank" >RIV/00216224:14110/25:00144445 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology

Popis výsledku v původním jazyce

Mechanosensation and mechanotransduction are critical processes in various biological systems, underpinning development, regeneration, and tissue repair. Mice possess continuously growing incisors that renew throughout their lifespan, offering an exceptional model for studying tissue homeostasis and regeneration. Despite the known importance of stem cell activity in the dental pulp for incisor renewal, the mechanisms controlling this process, particularly in response to mechanical stimuli or injury, remain unclear. In this study, we aimed to elucidate how mechanical stimuli or injury influence normal incisor growth using a tooth-clipping injury model. Furthermore, we examined whether clipping injury triggers phenotypical changes and alters the mechanical properties of the tooth and the surrounding alveolar bone. Finally, at the cellular level, we analyzed signaling adaptations in tooth-forming cells and elucidated changes in cell proliferation dynamics within the stem cell niche. Our findings reveal that incisor shortening induces complex phenotypical changes, influencing both cellular behavior and molecular signaling. The insights from this study shed light on how mechanical cues modulate structural and functional dynamics of incisor regeneration, providing a deeper understanding of the role of mechanosensing in tooth renewal and adaptation.

Název v anglickém jazyce

Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology

Popis výsledku anglicky

Mechanosensation and mechanotransduction are critical processes in various biological systems, underpinning development, regeneration, and tissue repair. Mice possess continuously growing incisors that renew throughout their lifespan, offering an exceptional model for studying tissue homeostasis and regeneration. Despite the known importance of stem cell activity in the dental pulp for incisor renewal, the mechanisms controlling this process, particularly in response to mechanical stimuli or injury, remain unclear. In this study, we aimed to elucidate how mechanical stimuli or injury influence normal incisor growth using a tooth-clipping injury model. Furthermore, we examined whether clipping injury triggers phenotypical changes and alters the mechanical properties of the tooth and the surrounding alveolar bone. Finally, at the cellular level, we analyzed signaling adaptations in tooth-forming cells and elucidated changes in cell proliferation dynamics within the stem cell niche. Our findings reveal that incisor shortening induces complex phenotypical changes, influencing both cellular behavior and molecular signaling. The insights from this study shed light on how mechanical cues modulate structural and functional dynamics of incisor regeneration, providing a deeper understanding of the role of mechanosensing in tooth renewal and adaptation.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

<a href="/cs/project/GA25-18087S" target="_blank" >GA25-18087S: Buněčná podstata hojení zubu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů