Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00122004" target="_blank" >RIV/00216224:14160/21:00122004 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-1-22/vliv-zpusobu-emulgace-rychlosti-michani-a-objemu-na-plga-mikrocastice-s-ibuprofenem-126748" target="_blank" >https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-1-22/vliv-zpusobu-emulgace-rychlosti-michani-a-objemu-na-plga-mikrocastice-s-ibuprofenem-126748</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles

Popis výsledku v původním jazyce

Microparticles based on biodegradable synthetic lactic acid and glycolic acid copolymer (PLGA) were successfully prepared by the solvent evaporation method. Ibuprofen was chosen as the model drug. Various formulation and process parameters have been used to prepare each sample with emphasis on size reduction. The effect of the emulsification method (direct emulsification or emulsification using an ULTRATURRAX or a NE-1000 dispenser), the volume of the aqueous phase (200, 800 ml) and the stirring speed of the emulsion system (600, 1000 rpm) on the characteristic properties of microparticles, such as encapsulation efficiency, drug loading and particle morphology, was observed. The resulting microparticles were evaluated by optical microscopy or laser diffraction and the dissolution test was performed. It was found that the sample prepared by direct emulsification with 800 ml of an aqueous phase at 600 rpm provided the most favorable results, meanwhile the emulsification prestep using a homogenizer caused promising particle size reduction. Gradual emulsification was evaluated as inapplicable due to great losses.

Název v anglickém jazyce

Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles

Popis výsledku anglicky

Microparticles based on biodegradable synthetic lactic acid and glycolic acid copolymer (PLGA) were successfully prepared by the solvent evaporation method. Ibuprofen was chosen as the model drug. Various formulation and process parameters have been used to prepare each sample with emphasis on size reduction. The effect of the emulsification method (direct emulsification or emulsification using an ULTRATURRAX or a NE-1000 dispenser), the volume of the aqueous phase (200, 800 ml) and the stirring speed of the emulsion system (600, 1000 rpm) on the characteristic properties of microparticles, such as encapsulation efficiency, drug loading and particle morphology, was observed. The resulting microparticles were evaluated by optical microscopy or laser diffraction and the dissolution test was performed. It was found that the sample prepared by direct emulsification with 800 ml of an aqueous phase at 600 rpm provided the most favorable results, meanwhile the emulsification prestep using a homogenizer caused promising particle size reduction. Gradual emulsification was evaluated as inapplicable due to great losses.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Svazek periodika

70

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

32-40

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85111416545