Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872054" target="_blank" >RIV/62157124:16370/13:43872054 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release

Popis výsledku v původním jazyce

PLGA microparticles for sustained release of ibuprofen as the model drug were prepared by O/W solvent evaporation method under altering stirring speed (600, 1000 rpm), emulsifier concentration (PVA concentration 0.1%, 1%) and organic solvent selection (dichloromethane, ethyl acetate). Obtained results confirmed the effect of selected formulation and process parameters on properties of prepared PLGA-based microparticles. The influence on encapsulation efficiency, yield, morphological properties, mean size and drug release was observed. The increased stirring speed within the solvent evaporation process led to decrease of encapsulation efficiency, yield and mean size but incorporated drug was released faster. Increased PVA concentration in external emulsion phase brought same results except ibuprofen release rate. Microparticles prepared with dichloromethane as the organic solvent exhibit higher sphericity, more regular shape with smooth surface, thus dichloromethane was considered as mo

Název v anglickém jazyce

Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release

Popis výsledku anglicky

PLGA microparticles for sustained release of ibuprofen as the model drug were prepared by O/W solvent evaporation method under altering stirring speed (600, 1000 rpm), emulsifier concentration (PVA concentration 0.1%, 1%) and organic solvent selection (dichloromethane, ethyl acetate). Obtained results confirmed the effect of selected formulation and process parameters on properties of prepared PLGA-based microparticles. The influence on encapsulation efficiency, yield, morphological properties, mean size and drug release was observed. The increased stirring speed within the solvent evaporation process led to decrease of encapsulation efficiency, yield and mean size but incorporated drug was released faster. Increased PVA concentration in external emulsion phase brought same results except ibuprofen release rate. Microparticles prepared with dichloromethane as the organic solvent exhibit higher sphericity, more regular shape with smooth surface, thus dichloromethane was considered as mo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Svazek periodika

62

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

120-126

Kód UT WoS článku

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EID výsledku v databázi Scopus

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