The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873124" target="_blank" >RIV/62157124:16370/14:43873124 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2478/acph-2014-0032" target="_blank" >http://dx.doi.org/10.2478/acph-2014-0032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/acph-2014-0032" target="_blank" >10.2478/acph-2014-0032</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

Popis výsledku v původním jazyce

The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirring speed of a mechanical stirrer (600, 1000 rpm), emulsifier concentrations (PVA concentration 0.1 %, 1 %) and solvent selection (dichlormethane, ethyl acetate) on microparticles characteristics (encapsulation efficiency, drug loading, burst effect) were observed. It was found that with increased stirring speed, the PVA concentration or the use of ethyl acetate had a significantly negative effect on encapsulation efficiency. In addition, ethyl acetate had anadverse effect on the burst effect, while the increased stirring speed had the opposite effect. Drug load was not affected by any individual variable, but rather by the interactions of evaluated variables.

Název v anglickém jazyce

The influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

Popis výsledku anglicky

The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirring speed of a mechanical stirrer (600, 1000 rpm), emulsifier concentrations (PVA concentration 0.1 %, 1 %) and solvent selection (dichlormethane, ethyl acetate) on microparticles characteristics (encapsulation efficiency, drug loading, burst effect) were observed. It was found that with increased stirring speed, the PVA concentration or the use of ethyl acetate had a significantly negative effect on encapsulation efficiency. In addition, ethyl acetate had anadverse effect on the burst effect, while the increased stirring speed had the opposite effect. Drug load was not affected by any individual variable, but rather by the interactions of evaluated variables.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta pharmaceutica

ISSN

1330-0075

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

15

Strana od-do

403-417

Kód UT WoS článku

000346704800002

EID výsledku v databázi Scopus

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