DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126649" target="_blank" >RIV/00216224:14160/22:00126649 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

Popis výsledku v původním jazyce

Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.

Název v anglickém jazyce

DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

Popis výsledku anglicky

Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30107 - Medicinal chemistry

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Czech Chemical Society Symposium Series

ISBN

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ISSN

2336-7202

e-ISSN

2336-7210

Počet stran výsledku

2

Strana od-do

28-29

Název nakladatele

Czech Chemical Society

Místo vydání

Pague, Czech republic

Místo konání akce

Milovy, Czech Republic

Datum konání akce

1. 1. 2022

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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