SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126659" target="_blank" >RIV/00216224:14160/22:00126659 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
Popis výsledku v původním jazyce
Many Schiff bases appear to be important intermediates in a number of enzymatic reactions. The presence of the azomethine group, as well as their interesting physical and chemical properties, cause the widespread application of their metal complexes. Synthesized groups of basic thiosemicarbazone and semicarbazone derivatives of acetophenone have these properties as well. Aminopeptidase N (AP-N), or membrane alanyl aminopeptidase (m-AAP), is a neutral zinc-binding metallopeptidase that cleaves N-terminal residues from protein and peptides. This aminopeptidase turns out to be identical to the human cluster differentiation antigen CD13 expressed on the surface of myeloid progenitors and myeloid leukemia cells.
Název v anglickém jazyce
SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
Popis výsledku anglicky
Many Schiff bases appear to be important intermediates in a number of enzymatic reactions. The presence of the azomethine group, as well as their interesting physical and chemical properties, cause the widespread application of their metal complexes. Synthesized groups of basic thiosemicarbazone and semicarbazone derivatives of acetophenone have these properties as well. Aminopeptidase N (AP-N), or membrane alanyl aminopeptidase (m-AAP), is a neutral zinc-binding metallopeptidase that cleaves N-terminal residues from protein and peptides. This aminopeptidase turns out to be identical to the human cluster differentiation antigen CD13 expressed on the surface of myeloid progenitors and myeloid leukemia cells.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30107 - Medicinal chemistry
Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů