SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00132384" target="_blank" >RIV/00216224:14160/23:00132384 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.2478/afpuc-2023-0022" target="_blank" >http://dx.doi.org/10.2478/afpuc-2023-0022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/afpuc-2023-0022" target="_blank" >10.2478/afpuc-2023-0022</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS
Popis výsledku v původním jazyce
Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
Název v anglickém jazyce
SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS
Popis výsledku anglicky
Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30107 - Medicinal chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/EF19_073%2F0016943" target="_blank" >EF19_073/0016943: Interní grantová agentura Masarykovy univerzity</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů