Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126880" target="_blank" >RIV/00216224:14160/22:00126880 - isvavai.cz</a>

Výsledek na webu

<a href="https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf" target="_blank" >https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application

Popis výsledku v původním jazyce

In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), chitosan (encapsulation), and leucine (reduction of hygroscopicity, anti-adherent). Every approach led to spherical particles, but only increasing the content of leucine generated separated particles showing the best results in 20-25 % of solid content. However, further research is needed to decrease particle size.

Název v anglickém jazyce

Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application

Popis výsledku anglicky

In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), chitosan (encapsulation), and leucine (reduction of hygroscopicity, anti-adherent). Every approach led to spherical particles, but only increasing the content of leucine generated separated particles showing the best results in 20-25 % of solid content. However, further research is needed to decrease particle size.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů