Preparation of spray-dried microparticles containing N-acetylcysteine for lung application
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00126946" target="_blank" >RIV/00216224:14160/21:00126946 - isvavai.cz</a>
Výsledek na webu
<a href="https://munispace.muni.cz/library/catalog/book/1984?fbclid=IwAR21tjHoFJ6YKyAm7QhFgrJnyUUaCZVWGZYeO0VL4_HxPWtKRUX56zMVNSI" target="_blank" >https://munispace.muni.cz/library/catalog/book/1984?fbclid=IwAR21tjHoFJ6YKyAm7QhFgrJnyUUaCZVWGZYeO0VL4_HxPWtKRUX56zMVNSI</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Preparation of spray-dried microparticles containing N-acetylcysteine for lung application
Popis výsledku v původním jazyce
In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation in mannitol carrier and with the addition of leucine as anti-adherent. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), and chitosan (encapsulation). Every approach led to spherical particles, but not individually separated and of the desired size. The results represent a reasonable basis for further development.
Název v anglickém jazyce
Preparation of spray-dried microparticles containing N-acetylcysteine for lung application
Popis výsledku anglicky
In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation in mannitol carrier and with the addition of leucine as anti-adherent. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), and chitosan (encapsulation). Every approach led to spherical particles, but not individually separated and of the desired size. The results represent a reasonable basis for further development.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů