Voriconazole pharmacokinetic models - comparing two softwares

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F24%3A00136390" target="_blank" >RIV/00216224:14160/24:00136390 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Voriconazole pharmacokinetic models - comparing two softwares

Popis výsledku v původním jazyce

Voriconazole (VRC), a second-generation azole antifungal, is the first choice for the treatment of Aspergillus infections. VRC is a drug with significant intra- and inter-individual variability, therapeutic monitoring (TDM) of voriconazole is therefore recommended for most patients according to currently valid international standards. However, the full potential of TDM in clinical practice can be exploited based on pharmacokinetic models with high predictive power that are not currently available for specific patient populations. The aim is to compare two pharmacokinetic models in the context of measured plasma concentrations of VRC in real patients.

Název v anglickém jazyce

Voriconazole pharmacokinetic models - comparing two softwares

Popis výsledku anglicky

Voriconazole (VRC), a second-generation azole antifungal, is the first choice for the treatment of Aspergillus infections. VRC is a drug with significant intra- and inter-individual variability, therapeutic monitoring (TDM) of voriconazole is therefore recommended for most patients according to currently valid international standards. However, the full potential of TDM in clinical practice can be exploited based on pharmacokinetic models with high predictive power that are not currently available for specific patient populations. The aim is to compare two pharmacokinetic models in the context of measured plasma concentrations of VRC in real patients.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30500 - Other medical sciences

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů