Effect of direct adrenaline infusion into isolated rat heart on the induction of ventricular tachyarrhythmias

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00140697" target="_blank" >RIV/00216224:14160/25:00140697 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2215016125000780" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2215016125000780</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mex.2025.103231" target="_blank" >10.1016/j.mex.2025.103231</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of direct adrenaline infusion into isolated rat heart on the induction of ventricular tachyarrhythmias

Popis výsledku v původním jazyce

In this study, hearts from 72 male Wistar albino rats were divided into two main protocols: a 40 min ischemia group (protocol A, n = 53) and 10 min ischemia group (protocol B, n = 19). Protocol A subdivided into 2 groups as a control group (n = 10) and adrenaline group (n = 43). Protocol B is subdivided into 2 groups as control group (n = 10) and adrenaline group (n = 9). Both adrenaline groups received the same dose of adrenaline. • In protocol A, ventricular tachyarrhythmia (VTA) incidence was 0 % in controls but rose to 72 % in the adrenaline group (p &lt; 0.01). Heart rates for the control and adrenaline groups in stabilization and reperfusion were 254±45 bpm and 247 ± 66 bpm, versus 277 ± 41 bpm and 651 ± 286 bpm, respectively. • In protocol B, VTA incidence reached 100 % in both groups during reperfusion, with heart rates of 393 ± 29 bpm and 892±227 bpm for controls and 350 ± 49 bpm and 949 ± 116 bpm for the adrenaline group. • These findings suggest that direct adrenaline administration into the heart in last 5 mins of the ischemic period and the 5 mins of in the reperfusion time increases the incidence of reperfusion-induced ventricular arrhythmias up to 72 % in protocol A. Protocol B hearts showed reperfusion-induced ventricular arrhythmias with 100 % incidence in both groups.

Název v anglickém jazyce

Effect of direct adrenaline infusion into isolated rat heart on the induction of ventricular tachyarrhythmias

Popis výsledku anglicky

In this study, hearts from 72 male Wistar albino rats were divided into two main protocols: a 40 min ischemia group (protocol A, n = 53) and 10 min ischemia group (protocol B, n = 19). Protocol A subdivided into 2 groups as a control group (n = 10) and adrenaline group (n = 43). Protocol B is subdivided into 2 groups as control group (n = 10) and adrenaline group (n = 9). Both adrenaline groups received the same dose of adrenaline. • In protocol A, ventricular tachyarrhythmia (VTA) incidence was 0 % in controls but rose to 72 % in the adrenaline group (p &lt; 0.01). Heart rates for the control and adrenaline groups in stabilization and reperfusion were 254±45 bpm and 247 ± 66 bpm, versus 277 ± 41 bpm and 651 ± 286 bpm, respectively. • In protocol B, VTA incidence reached 100 % in both groups during reperfusion, with heart rates of 393 ± 29 bpm and 892±227 bpm for controls and 350 ± 49 bpm and 949 ± 116 bpm for the adrenaline group. • These findings suggest that direct adrenaline administration into the heart in last 5 mins of the ischemic period and the 5 mins of in the reperfusion time increases the incidence of reperfusion-induced ventricular arrhythmias up to 72 % in protocol A. Protocol B hearts showed reperfusion-induced ventricular arrhythmias with 100 % incidence in both groups.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

METHODSX

ISSN

2215-0161

e-ISSN

2215-0161

Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

1-12

Kód UT WoS článku

001435426700001

EID výsledku v databázi Scopus

2-s2.0-85219068387