PREPARATION OF AMINO-FUNCTIONALIZED THC DERIVATIVES AS POTENTIAL BIOACTIVE COMPOUNDS

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

PREPARATION OF AMINO-FUNCTIONALIZED THC DERIVATIVES AS POTENTIAL BIOACTIVE COMPOUNDS

Popis výsledku v původním jazyce

Tetrahydrocannabinol (THC) is the main psychoactive component of Cannabis sativa and a ligand of the cannabinoid receptors CB1 and CB2. These G-protein-coupled receptors are part of the endocannabinoid system, which regulates a wide array of physiological processes. Although THC and its analogues exhibits a wide range of biological activities through its interaction with cannabinoid receptors, their clinical use is limited by poor water solubility, psychoactive side effects, and insufficient receptor selectivity [2]. Chemical modification of the THC structure represents a promising strategy to overcome these limitations and generate new compounds with improved pharmacokinetic and pharmacodynamic profiles. The introduction of amino group offers multiple advantages: increased solubility, the ability for salt formation, better receptor interaction via hydrogen bonding or electrostatic forces, and access to a broad range of further derivatization.

Název v anglickém jazyce

PREPARATION OF AMINO-FUNCTIONALIZED THC DERIVATIVES AS POTENTIAL BIOACTIVE COMPOUNDS

Popis výsledku anglicky

Tetrahydrocannabinol (THC) is the main psychoactive component of Cannabis sativa and a ligand of the cannabinoid receptors CB1 and CB2. These G-protein-coupled receptors are part of the endocannabinoid system, which regulates a wide array of physiological processes. Although THC and its analogues exhibits a wide range of biological activities through its interaction with cannabinoid receptors, their clinical use is limited by poor water solubility, psychoactive side effects, and insufficient receptor selectivity [2]. Chemical modification of the THC structure represents a promising strategy to overcome these limitations and generate new compounds with improved pharmacokinetic and pharmacodynamic profiles. The introduction of amino group offers multiple advantages: increased solubility, the ability for salt formation, better receptor interaction via hydrogen bonding or electrostatic forces, and access to a broad range of further derivatization.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10400 - Chemical sciences

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů