Malonyl-Caffeoylquinic Acids and Malonyl-Flavonoid-Glucosides from Three Edible Apiaceae Plants Anthriscus Cerefolium, Anthriscus Sylvestris, and Chaerophyllum Bulbosum
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00143915" target="_blank" >RIV/00216224:14160/25:00143915 - isvavai.cz</a>
Výsledek na webu
<a href="https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c03770?utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c03770?utm_source=clarivate&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.5c03770" target="_blank" >10.1021/acsomega.5c03770</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Malonyl-Caffeoylquinic Acids and Malonyl-Flavonoid-Glucosides from Three Edible Apiaceae Plants Anthriscus Cerefolium, Anthriscus Sylvestris, and Chaerophyllum Bulbosum
Popis výsledku v původním jazyce
Novel compounds, including four isomeric monomalonyl-dicaffeoylquinic acids (4-7), one dimalonyl-dicaffeoylquinic acid (9), and one flavonoid-dimalonyl-glucoside (8), along with three known flavonoid-monomalonyl-glucosides (1-3), were discovered in closely related edible Apiaceae plants: Anthriscus cerefolium, Anthriscus sylvestris, and Chaerophyllum bulbosum. Their structures were elucidated through comprehensive HPLC-UV-HR-MS/MS and NMR analyses, and isomeric malonyl-dicaffeoylquinic acids (4-7) were differentiated based on HPLC-MS/MS fragmentation characteristics. The study confirmed organ- and vegetation phase-specific accumulation, identifying optimal plant tissues for targeted isolation using a one-step preparative HPLC method. Malonyl-dicaffeoylquinic acids 4 and 9 exhibited significant cytotoxicity to nontumorous Vero E6 cells in vitro (IC50 < 10 mu M). At the same time, the isolated compounds displayed structure-specific DPPH radical scavenging activity, underscoring their dual biological relevance.
Název v anglickém jazyce
Malonyl-Caffeoylquinic Acids and Malonyl-Flavonoid-Glucosides from Three Edible Apiaceae Plants Anthriscus Cerefolium, Anthriscus Sylvestris, and Chaerophyllum Bulbosum
Popis výsledku anglicky
Novel compounds, including four isomeric monomalonyl-dicaffeoylquinic acids (4-7), one dimalonyl-dicaffeoylquinic acid (9), and one flavonoid-dimalonyl-glucoside (8), along with three known flavonoid-monomalonyl-glucosides (1-3), were discovered in closely related edible Apiaceae plants: Anthriscus cerefolium, Anthriscus sylvestris, and Chaerophyllum bulbosum. Their structures were elucidated through comprehensive HPLC-UV-HR-MS/MS and NMR analyses, and isomeric malonyl-dicaffeoylquinic acids (4-7) were differentiated based on HPLC-MS/MS fragmentation characteristics. The study confirmed organ- and vegetation phase-specific accumulation, identifying optimal plant tissues for targeted isolation using a one-step preparative HPLC method. Malonyl-dicaffeoylquinic acids 4 and 9 exhibited significant cytotoxicity to nontumorous Vero E6 cells in vitro (IC50 < 10 mu M). At the same time, the isolated compounds displayed structure-specific DPPH radical scavenging activity, underscoring their dual biological relevance.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10400 - Chemical sciences
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
ACS Omega
ISSN
2470-1343
e-ISSN
—
Svazek periodika
10
Číslo periodika v rámci svazku
38
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
13
Strana od-do
43656-43668
Kód UT WoS článku
001577809300001
EID výsledku v databázi Scopus
2-s2.0-105017404965