Glycosyltransferase prediction in Mycobacterium tuberculosis genome by threading

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F02%3A00007106" target="_blank" >RIV/00216224:14310/02:00007106 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Glycosyltransferase prediction in Mycobacterium tuberculosis genome by threading

Popis výsledku v původním jazyce

Mycobacterium tuberculosis is a intracellular pathogen of the alveolar macrophages in lung resistant to most common antibiotics and chemotherapeutic agents. This resistance is related to its unusual and well-organized cell wall that contains the unique structures of branched and complex polysaccharides and glycolipids. The main cell wall constituents are known but there is only little information about the key enzymes in their biosynthesis, glycosyltransferases (GT). The genome of M. tuberculosis contains 3,951 protein-coding sequences. Putative function annotation of some of them was predicted using a combination of sequence alignment and motif comparison. Using this approach, only a small number of putative GTs was identified. Recently, only nine crystal structures of GTs have been solved. There is very low sequence similarity among them and they belong to different family groups. On the other hand, solving of their crystal structures demonstrated that they adopt only two basic 3D-fo

Název v anglickém jazyce

Glycosyltransferase prediction in Mycobacterium tuberculosis genome by threading

Popis výsledku anglicky

Mycobacterium tuberculosis is a intracellular pathogen of the alveolar macrophages in lung resistant to most common antibiotics and chemotherapeutic agents. This resistance is related to its unusual and well-organized cell wall that contains the unique structures of branched and complex polysaccharides and glycolipids. The main cell wall constituents are known but there is only little information about the key enzymes in their biosynthesis, glycosyltransferases (GT). The genome of M. tuberculosis contains 3,951 protein-coding sequences. Putative function annotation of some of them was predicted using a combination of sequence alignment and motif comparison. Using this approach, only a small number of putative GTs was identified. Recently, only nine crystal structures of GTs have been solved. There is very low sequence similarity among them and they belong to different family groups. On the other hand, solving of their crystal structures demonstrated that they adopt only two basic 3D-fo

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

3rd International Symposium on Glycosyltransferases

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

112

Název nakladatele

Lund University

Místo vydání

Stockholm

Místo konání akce

September 19 - 22, Djuronaset, Stockholm, Sweden

Datum konání akce

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Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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