Glycosyltransferase Fold Recognition Analysis of the Mycobacterium Tuberculosis Genome Sequence

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F02%3A00007107" target="_blank" >RIV/00216224:14310/02:00007107 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Glycosyltransferase Fold Recognition Analysis of the Mycobacterium Tuberculosis Genome Sequence

Popis výsledku v původním jazyce

There is very little knowledge about enzymes involved in the biosynthesis of unique and unusual cell wall structure of M. tuberculosis, the leading cause of human death. The genome M. tuberculosis contains 3,951 protein-coding sequences. Putative function of some of them was predicted using a combination of sequence alignment and motif comparison [1]. Using this approach, only a small number of putative GTs was identified. Recent crystal structure determination of GTs demonstrated that they adopt a limited number of topology that can be characterized using fold recognition approach [2]. We therefore proposed first to focus on 3D-topology identification of potential GTs in M. tuberculosis and second to apply this method to the complete amino acid sequences encoded by the M. tuberculosis (http://genolist.pasteur.fr/TubercuList/). The ProCeryon program that is based on Knowledge-Based Potentials [3] was used with parameters optimised on existing structures of GTs. This approach allows to

Název v anglickém jazyce

Glycosyltransferase Fold Recognition Analysis of the Mycobacterium Tuberculosis Genome Sequence

Popis výsledku anglicky

There is very little knowledge about enzymes involved in the biosynthesis of unique and unusual cell wall structure of M. tuberculosis, the leading cause of human death. The genome M. tuberculosis contains 3,951 protein-coding sequences. Putative function of some of them was predicted using a combination of sequence alignment and motif comparison [1]. Using this approach, only a small number of putative GTs was identified. Recent crystal structure determination of GTs demonstrated that they adopt a limited number of topology that can be characterized using fold recognition approach [2]. We therefore proposed first to focus on 3D-topology identification of potential GTs in M. tuberculosis and second to apply this method to the complete amino acid sequences encoded by the M. tuberculosis (http://genolist.pasteur.fr/TubercuList/). The ProCeryon program that is based on Knowledge-Based Potentials [3] was used with parameters optimised on existing structures of GTs. This approach allows to

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A016" target="_blank" >LN00A016: BIOMOLEKULÁRNÍ CENTRUM</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

XIV International Biophysics Congress, IUPAB

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

58

Název nakladatele

IUPAB

Místo vydání

Buenos Aires

Místo konání akce

April 27-May 1, Buenos Aires, Argentina

Datum konání akce

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Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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