Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F03%3A00009628" target="_blank" >RIV/00216224:14310/03:00009628 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/03:00008746

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents

Popis výsledku v původním jazyce

Ln(III) complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) and their analogues are used for their high thermodynamic stability, kinetic inertness and other properties as MRI or luminescent probes in medicine. New analogues of DOTA were prepared by substitution of one acetic group by pendant groups containing phosphonic group. The formation kinetics between Eu(III) and recently synthesized ligands were studied under experimental conditions (t = 25 oC, I = 0.1 mol.l-1, pH = 4-6) by means of UV/VIS absorption spectroscopy and two steps were observed: Eu3+ + HxL <=> (x-y)H+ + Eu(HyL) --> Eu(L) + yH+ The first step - the coordination of Eu(III) ion by pendant groups is very fast. In the second step, the transformation of an intermediate to the final complex in which Eu(III) ion is coordinated by four pendant groups and four nitrogen donor atoms of the cyclen ring, takes place. This step is very slow and it is proportional to OH- ion concentration. The estimates of prot

Název v anglickém jazyce

Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents

Popis výsledku anglicky

Ln(III) complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) and their analogues are used for their high thermodynamic stability, kinetic inertness and other properties as MRI or luminescent probes in medicine. New analogues of DOTA were prepared by substitution of one acetic group by pendant groups containing phosphonic group. The formation kinetics between Eu(III) and recently synthesized ligands were studied under experimental conditions (t = 25 oC, I = 0.1 mol.l-1, pH = 4-6) by means of UV/VIS absorption spectroscopy and two steps were observed: Eu3+ + HxL <=> (x-y)H+ + Eu(HyL) --> Eu(L) + yH+ The first step - the coordination of Eu(III) ion by pendant groups is very fast. In the second step, the transformation of an intermediate to the final complex in which Eu(III) ion is coordinated by four pendant groups and four nitrogen donor atoms of the cyclen ring, takes place. This step is very slow and it is proportional to OH- ion concentration. The estimates of prot

Druh

D - Stať ve sborníku

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Abstract Book of Conference "TOWARDS MOLECULAR ELECTRONICS" (Central European Conference on Advanced Materials and Nanotechnology), Srem, Poland, June 23-28, 2003.

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

105

Název nakladatele

Adam Mickiewicz University

Místo vydání

Poznan

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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