GRAFT VERSUS HOST DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION AND ITS PREDICTION BY PROTEOMIC APPROACHES
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00022291" target="_blank" >RIV/00216224:14310/07:00022291 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
GRAFT VERSUS HOST DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION AND ITS PREDICTION BY PROTEOMIC APPROACHES
Popis výsledku v původním jazyce
Background: Acute graft versus host disease (GvHD) is a frequent complication of allogeneic stem cells transplantation (alloSCT). The rapid diagnosis of acute GvHD following alloSCT is important for optimizing the management of this life-threatening complication. Differentially expressed or excreted polypeptides and proteins have potential for early and accurate diagnosis of GvHD and other complications of allo-SCT. Aims: Search for blood plasma proteins useful as potential biomarkers for early detection of GvHD. Methods: 2-dimensional gel electrophoresis (2-DE) was used for separation of blood plasma proteins. Proteins considered as potential biomarkers for early prediction of GvHD were selected by image analysis. Protein spots with different expression levels were characterized by matrix-assisted laser desorption/ionization - time of flight mass spectrometry (MALDI-TOF-MS) using peptide mass fingerprinting.
Název v anglickém jazyce
GRAFT VERSUS HOST DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION AND ITS PREDICTION BY PROTEOMIC APPROACHES
Popis výsledku anglicky
Background: Acute graft versus host disease (GvHD) is a frequent complication of allogeneic stem cells transplantation (alloSCT). The rapid diagnosis of acute GvHD following alloSCT is important for optimizing the management of this life-threatening complication. Differentially expressed or excreted polypeptides and proteins have potential for early and accurate diagnosis of GvHD and other complications of allo-SCT. Aims: Search for blood plasma proteins useful as potential biomarkers for early detection of GvHD. Methods: 2-dimensional gel electrophoresis (2-DE) was used for separation of blood plasma proteins. Proteins considered as potential biomarkers for early prediction of GvHD were selected by image analysis. Protein spots with different expression levels were characterized by matrix-assisted laser desorption/ionization - time of flight mass spectrometry (MALDI-TOF-MS) using peptide mass fingerprinting.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/LC06034" target="_blank" >LC06034: Regulace morfogeneze rostlinných buněk a orgánů</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2007
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů