Study the N-acetylglucosaminyltransferase V structure through homology modeling methods.
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00039163" target="_blank" >RIV/00216224:14310/09:00039163 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Study the N-acetylglucosaminyltransferase V structure through homology modeling methods.
Popis výsledku v původním jazyce
In the present study, we have attempted to build model of the GnT-V 3D-structure. We obtain altogether 10 models of the GnT-V structure. On the basis of the 3D-structure analysis we have chosen five models for the molecular dynamic equilibration in water. All structure models have been equilibrated at 300 K during 4ns. The molecular dynamic simulation show, that more reliable model might be the model based on the MurG template. Due to these result we did multiple sequence alignment with another seven members of this family, including MurG, to observe more precise alignment. In addition we also took one glycosyltransferase, which family has not been specified yet, a-1,6-fucosyltransferase FUT8 (2DE0).
Název v anglickém jazyce
Study the N-acetylglucosaminyltransferase V structure through homology modeling methods.
Popis výsledku anglicky
In the present study, we have attempted to build model of the GnT-V 3D-structure. We obtain altogether 10 models of the GnT-V structure. On the basis of the 3D-structure analysis we have chosen five models for the molecular dynamic equilibration in water. All structure models have been equilibrated at 300 K during 4ns. The molecular dynamic simulation show, that more reliable model might be the model based on the MurG template. Due to these result we did multiple sequence alignment with another seven members of this family, including MurG, to observe more precise alignment. In addition we also took one glycosyltransferase, which family has not been specified yet, a-1,6-fucosyltransferase FUT8 (2DE0).
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
CF - Fyzikální chemie a teoretická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2009
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů