STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040195" target="_blank" >RIV/00216224:14310/10:00040195 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE

Popis výsledku v původním jazyce

Direct N-monoacylation of piperazine was already described for its reaction with acyl chlorides or alkyl chlorocarbonates in acidified water (pH ca 3) with very bad yields - about 30 % of monoacyl piperazine. On the other hand, direct N-mono-benzylationof piperazine in the piperazinium chloride form by benzyl chloride in ethanol provides mono-product in excellent yield. N-monoacyl piperazines can be key building block in industrial piperazine chemistry, better than N-monobenzyl piperazine on the groundof facile deacylation. Possibilities for an application of cation-exchanger resins for better than described direct N-monoacylation reactions on piperazine by an action of different acylating agents in polar organic solvents were studied. For study bothtypes of resins, i. e. strong acid (sulfonated polystyrene-divinylbenzene copolymer) and weak acid (acrylic acid-divinylbenzene copolymer) as cation-exchanger resins were used.

Název v anglickém jazyce

STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE

Popis výsledku anglicky

Direct N-monoacylation of piperazine was already described for its reaction with acyl chlorides or alkyl chlorocarbonates in acidified water (pH ca 3) with very bad yields - about 30 % of monoacyl piperazine. On the other hand, direct N-mono-benzylationof piperazine in the piperazinium chloride form by benzyl chloride in ethanol provides mono-product in excellent yield. N-monoacyl piperazines can be key building block in industrial piperazine chemistry, better than N-monobenzyl piperazine on the groundof facile deacylation. Possibilities for an application of cation-exchanger resins for better than described direct N-monoacylation reactions on piperazine by an action of different acylating agents in polar organic solvents were studied. For study bothtypes of resins, i. e. strong acid (sulfonated polystyrene-divinylbenzene copolymer) and weak acid (acrylic acid-divinylbenzene copolymer) as cation-exchanger resins were used.

Druh

D - Stať ve sborníku

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/2A-1TP1%2F090" target="_blank" >2A-1TP1/090: Nové katalyzátory a činidla pro udržitelné zelené syntézy a kombinatoriální syntézy.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju<br>N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

XXIVth EUROPEAN COLLOQUIUM on HETEROCYCLIC CHEMISTRY

ISBN

978-3-9502992-0-5

ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

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Název nakladatele

Book-of-Abstracts.com

Místo vydání

Vienna, Austria

Místo konání akce

Vienna

Datum konání akce

1. 1. 2010

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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