Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040583" target="_blank" >RIV/00216224:14310/10:00040583 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells
Popis výsledku v původním jazyce
Wedelolactone is an active polyphenolic coumestan isolated from the plant extracts of Wedelia chinensis and Eclipta prostrata. Recently, wedelolactone has been shown to reduce growth cancer cells. These effects were attributed to the inhibition of NFkB and androgen receptors. In this study, we tested the effect of wedelolactone on proliferation, differentiation and apoptosis of breast cancer MDA-MB-231 cells. Wedelolactone in uM concentrations suppresses growth of MDA-MB-231 cells by blocking cell cycleprogression in the S- and G2/M phases. The 10 uM wedelolactone induces cell differentiation and the 30 uM wedelolactone reduces viability and induces apoptosis of MDA-MB-231 cells. We found that the growth inhibitory and proapoptotic effects of wedelolactone do not result from deregulation of NFkB activity but they are more likely to be attributed to its ability to bind dsDNA, to inhibit topoisomerase IIa and to induce DNA damage.
Název v anglickém jazyce
Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells
Popis výsledku anglicky
Wedelolactone is an active polyphenolic coumestan isolated from the plant extracts of Wedelia chinensis and Eclipta prostrata. Recently, wedelolactone has been shown to reduce growth cancer cells. These effects were attributed to the inhibition of NFkB and androgen receptors. In this study, we tested the effect of wedelolactone on proliferation, differentiation and apoptosis of breast cancer MDA-MB-231 cells. Wedelolactone in uM concentrations suppresses growth of MDA-MB-231 cells by blocking cell cycleprogression in the S- and G2/M phases. The 10 uM wedelolactone induces cell differentiation and the 30 uM wedelolactone reduces viability and induces apoptosis of MDA-MB-231 cells. We found that the growth inhibitory and proapoptotic effects of wedelolactone do not result from deregulation of NFkB activity but they are more likely to be attributed to its ability to bind dsDNA, to inhibit topoisomerase IIa and to induce DNA damage.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2010
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů