Inhibition of topoisomerase II alpha: Novel function of wedelolactone

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F11%3A00440847" target="_blank" >RIV/68081707:_____/11:00440847 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.canlet.2011.01.002" target="_blank" >http://dx.doi.org/10.1016/j.canlet.2011.01.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canlet.2011.01.002" target="_blank" >10.1016/j.canlet.2011.01.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Inhibition of topoisomerase II alpha: Novel function of wedelolactone

Popis výsledku v původním jazyce

The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NF kappa B transcription factor and/orandrogen receptors. We found that wedelolactone suppressed growth and induced apoptosis of androgen receptor-negative MDA-MB-231 breast cancer cells at concentrations that did not inhibit the NF kappa B activity. The cells responded to wedelolactone bythe S and G2/M phase cell cycle arrest and induction of the DNA damage signaling. Wedelolactone interacted with dsDNA and inhibited the activity of DNA topoisomerase II alpha. We conclude that wedelolactone can act as growth suppressor independently of NF kappa B and androgen receptors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Název v anglickém jazyce

Inhibition of topoisomerase II alpha: Novel function of wedelolactone

Popis výsledku anglicky

The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NF kappa B transcription factor and/orandrogen receptors. We found that wedelolactone suppressed growth and induced apoptosis of androgen receptor-negative MDA-MB-231 breast cancer cells at concentrations that did not inhibit the NF kappa B activity. The cells responded to wedelolactone bythe S and G2/M phase cell cycle arrest and induction of the DNA damage signaling. Wedelolactone interacted with dsDNA and inhibited the activity of DNA topoisomerase II alpha. We conclude that wedelolactone can act as growth suppressor independently of NF kappa B and androgen receptors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer letters

ISSN

0304-3835

e-ISSN

—

Svazek periodika

303

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

29-38

Kód UT WoS článku

000288820100004

EID výsledku v databázi Scopus

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