Using the FISH method for an identification of genetic alterations in cervical carcinoma ane cervical intraepithelial neoplasia: gain of human telomerase gene (hTERC)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00044840" target="_blank" >RIV/00216224:14310/10:00044840 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Using the FISH method for an identification of genetic alterations in cervical carcinoma ane cervical intraepithelial neoplasia: gain of human telomerase gene (hTERC)

Popis výsledku v původním jazyce

Cervical cancer is the second most common cancer in women in the Czech Republic, approximately 400 women die of this disease every year. It is known that this carcinoma develops from precancerous cervical intraepithelial neoplasia (CIN) which is characterized by series of genetic abnormalities. Gain of hTERC (3q26) was the most consistent chromosomal abnormality found in cervical carcinoma. It was discovered that gain of hTERC gene is associated with progression from precansers (CIN1, CIN2, CIN3) to cervical carcinoma. In our work, we studied copy number changes of the chromosomal region of hTERC gene using the FISH method in cytological smears obtained from 30 patients of the Departement of Gynaecological Oncology of Masaryk Memorial Cancer InstituteBrno. Gain of hTERC gene was found in 16 from 30 (53 %) patiens with the diagnosis of cervical cancer or with CIN1-CIN3. It was confirmed that gain of hTERC is significantly associated with cervical carcinoma.

Název v anglickém jazyce

Using the FISH method for an identification of genetic alterations in cervical carcinoma ane cervical intraepithelial neoplasia: gain of human telomerase gene (hTERC)

Popis výsledku anglicky

Cervical cancer is the second most common cancer in women in the Czech Republic, approximately 400 women die of this disease every year. It is known that this carcinoma develops from precancerous cervical intraepithelial neoplasia (CIN) which is characterized by series of genetic abnormalities. Gain of hTERC (3q26) was the most consistent chromosomal abnormality found in cervical carcinoma. It was discovered that gain of hTERC gene is associated with progression from precansers (CIN1, CIN2, CIN3) to cervical carcinoma. In our work, we studied copy number changes of the chromosomal region of hTERC gene using the FISH method in cytological smears obtained from 30 patients of the Departement of Gynaecological Oncology of Masaryk Memorial Cancer InstituteBrno. Gain of hTERC gene was found in 16 from 30 (53 %) patiens with the diagnosis of cervical cancer or with CIN1-CIN3. It was confirmed that gain of hTERC is significantly associated with cervical carcinoma.

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů