Association between major histocompatibility complex class IIB alleles and metazoan parasite load in populations of European chub (Leuciscus cephalus): testing of balancing selection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00045467" target="_blank" >RIV/00216224:14310/10:00045467 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Association between major histocompatibility complex class IIB alleles and metazoan parasite load in populations of European chub (Leuciscus cephalus): testing of balancing selection

Popis výsledku v původním jazyce

The genes of major histocompatibility complex (MHC), the most polymorphic loci known in vertebrates, have become the most studied genes in molecular ecology because they represent one of the best candidates suitable to study natural selection on a molecular level in the wild populations. The extremely high level of MHC allelic diversity is result of many mechanisms, especially the parasite-driven balancing selection, as well as recombination, gene duplication mutation and genetic drift. The main objectives of the present study were: a) to perform a sequence analysis of MHC class IIB alleles in European chub (Leuciscus cephalus), b) to investigate the contribution of evolutionary mechanisms (selection, recombination) to MHC diversity, and c) to analysethe co-evolutionary relationship between metazoan parasite load and MHC class IIB alleles. A total of 311 individuals from 15 populations of chub were collected from European rivers across a wide geographical range.

Název v anglickém jazyce

Association between major histocompatibility complex class IIB alleles and metazoan parasite load in populations of European chub (Leuciscus cephalus): testing of balancing selection

Popis výsledku anglicky

The genes of major histocompatibility complex (MHC), the most polymorphic loci known in vertebrates, have become the most studied genes in molecular ecology because they represent one of the best candidates suitable to study natural selection on a molecular level in the wild populations. The extremely high level of MHC allelic diversity is result of many mechanisms, especially the parasite-driven balancing selection, as well as recombination, gene duplication mutation and genetic drift. The main objectives of the present study were: a) to perform a sequence analysis of MHC class IIB alleles in European chub (Leuciscus cephalus), b) to investigate the contribution of evolutionary mechanisms (selection, recombination) to MHC diversity, and c) to analysethe co-evolutionary relationship between metazoan parasite load and MHC class IIB alleles. A total of 311 individuals from 15 populations of chub were collected from European rivers across a wide geographical range.

Druh

O - Ostatní výsledky

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů