Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049665" target="_blank" >RIV/00216224:14310/11:00049665 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00251-010-0495-3" target="_blank" >http://dx.doi.org/10.1007/s00251-010-0495-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00251-010-0495-3" target="_blank" >10.1007/s00251-010-0495-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe

Popis výsledku v původním jazyce

The polymorphism of exon 2 of the DAB genes (MHC class IIB) was investigated in the freshwater cyprinid fish species, Squalius cephalus in the wide range of its distribution in Europe. We identified 111 different DAB variants in 15 chub populations. Thesequence analysis showed that many structurally important amino acid sites that were conserved among tetrapods were also conserved in chub. The analysis of recombination indicated that it does not play an important role in producing and maintaining the variation of DAB genes analyzed in the present study. The exon 2 was shown to be subjected to intense positive selection. Phylogenetic analysis and sequence identities suggest the presence of two class IIB loci in chub. A contrasting selection pattern wasfound in DAB1-like and DAB3-like genes, which suggests the potential functional differences between these genes.

Název v anglickém jazyce

Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe

Popis výsledku anglicky

The polymorphism of exon 2 of the DAB genes (MHC class IIB) was investigated in the freshwater cyprinid fish species, Squalius cephalus in the wide range of its distribution in Europe. We identified 111 different DAB variants in 15 chub populations. Thesequence analysis showed that many structurally important amino acid sites that were conserved among tetrapods were also conserved in chub. The analysis of recombination indicated that it does not play an important role in producing and maintaining the variation of DAB genes analyzed in the present study. The exon 2 was shown to be subjected to intense positive selection. Phylogenetic analysis and sequence identities suggest the presence of two class IIB loci in chub. A contrasting selection pattern wasfound in DAB1-like and DAB3-like genes, which suggests the potential functional differences between these genes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunogenetics

ISSN

0093-7711

e-ISSN

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Svazek periodika

63

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

15

Strana od-do

167-181

Kód UT WoS článku

000287148700004

EID výsledku v databázi Scopus

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