Hemolymph clotting and immunity.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049751" target="_blank" >RIV/00216224:14310/11:00049751 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hemolymph clotting and immunity.

Popis výsledku v původním jazyce

We are interested in the clotting of insect hemolymph. Clotting in Drosophila involves the precipitation of clotting factors and crosslinking of the clot. The latter process is mediated through the activity of the two enzymes transglutaminase and phenoloxidase. Our recent work shows that in addition to sealing wounds clotting also has a major function in protecting Drosophila larvae from infections. Larvae with reduced expression of either clotting factors or transglutaminase are more susceptible to infections with certain bacteria. The most significant effects were observed when we infected larvae using a natural infection model involving entomopathogenic nematodes and their associated bacteria. Our most recent results show that while single mutants in several previously characterized immune pathways (such as the imd pathway) behave similar to normal larvae, double mutants succumb faster to the infection. For example Bc/imd double mutants show immune defects.

Název v anglickém jazyce

Hemolymph clotting and immunity.

Popis výsledku anglicky

We are interested in the clotting of insect hemolymph. Clotting in Drosophila involves the precipitation of clotting factors and crosslinking of the clot. The latter process is mediated through the activity of the two enzymes transglutaminase and phenoloxidase. Our recent work shows that in addition to sealing wounds clotting also has a major function in protecting Drosophila larvae from infections. Larvae with reduced expression of either clotting factors or transglutaminase are more susceptible to infections with certain bacteria. The most significant effects were observed when we infected larvae using a natural infection model involving entomopathogenic nematodes and their associated bacteria. Our most recent results show that while single mutants in several previously characterized immune pathways (such as the imd pathway) behave similar to normal larvae, double mutants succumb faster to the infection. For example Bc/imd double mutants show immune defects.

Druh

O - Ostatní výsledky

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GP206%2F09%2FP470" target="_blank" >GP206/09/P470: Vliv inhibitorů biosyntézy eikosanoidů na imunitu zavíječe voskového Galleria mellonella</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů