Antibacterial agents in innate immunity: comparison of vertebrates and invertebrates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049851" target="_blank" >RIV/00216224:14310/11:00049851 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antibacterial agents in innate immunity: comparison of vertebrates and invertebrates

Popis výsledku v původním jazyce

Innate immunity of both vertebrates and invertebrates contents number of antibacterial mechanisms. In invertebrates there is lysozyme and several different antibacterial peptides which are divided according to their stucture to four main groups called linear a-helical, cysteine-stabilized, proline-rich and glycine-rich inducible antimicrobial peptides. In vertebrates antibacterial components cooperate with antibodies, complement cascade and myeloperoxidase activity. Nowadays, many common methods for determination of non-specific innate immune parameters are known in vertebrates, nevertheless there is not so large variety of them in invertebrates. Therefore we tried to apply to invertebrates the bioluminescent bacteria-based assay which is commonly usedfor complement determination in vertebrates. Bioluminescent bacteria are frequent in salt water environment, but there is the only one genus of soil bacteria with natural bioluminescence ? Photorhabdus sp.

Název v anglickém jazyce

Antibacterial agents in innate immunity: comparison of vertebrates and invertebrates

Popis výsledku anglicky

Innate immunity of both vertebrates and invertebrates contents number of antibacterial mechanisms. In invertebrates there is lysozyme and several different antibacterial peptides which are divided according to their stucture to four main groups called linear a-helical, cysteine-stabilized, proline-rich and glycine-rich inducible antimicrobial peptides. In vertebrates antibacterial components cooperate with antibodies, complement cascade and myeloperoxidase activity. Nowadays, many common methods for determination of non-specific innate immune parameters are known in vertebrates, nevertheless there is not so large variety of them in invertebrates. Therefore we tried to apply to invertebrates the bioluminescent bacteria-based assay which is commonly usedfor complement determination in vertebrates. Bioluminescent bacteria are frequent in salt water environment, but there is the only one genus of soil bacteria with natural bioluminescence ? Photorhabdus sp.

Druh

O - Ostatní výsledky

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GP206%2F09%2FP470" target="_blank" >GP206/09/P470: Vliv inhibitorů biosyntézy eikosanoidů na imunitu zavíječe voskového Galleria mellonella</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů