Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00050132" target="_blank" >RIV/00216224:14310/11:00050132 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.envint.2011.03.016" target="_blank" >http://dx.doi.org/10.1016/j.envint.2011.03.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envint.2011.03.016" target="_blank" >10.1016/j.envint.2011.03.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter

Popis výsledku v původním jazyce

In vitro effects of binary mixtures of various DOM (mainly HS) with various HOCs on AhR-mediated responses were studied by use of H4IIE-luc cells. 6 out of 12 DOM activated the AhR even at environmentally relevant concentrations (17 mg L(-1)). In simultaneous exposures of H4IIE-luc cells to DOM and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of POPs, a mixture of PAHs, and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs. No significant decrease of effects due to sorption of HOCs to DOM was observed, even in subsequent experiments when HOCs + DOM mixtures were preincubated for six days before exposure to H4IIE-luc. Thus, DOM does not seem to protect organisms against AhR-mediated toxic effects of HOCs (as predicted due to sorption of HOCs on DOM), but it can enhance their potency for AhR-mediated effects in

Název v anglickém jazyce

Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter

Popis výsledku anglicky

In vitro effects of binary mixtures of various DOM (mainly HS) with various HOCs on AhR-mediated responses were studied by use of H4IIE-luc cells. 6 out of 12 DOM activated the AhR even at environmentally relevant concentrations (17 mg L(-1)). In simultaneous exposures of H4IIE-luc cells to DOM and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of POPs, a mixture of PAHs, and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs. No significant decrease of effects due to sorption of HOCs to DOM was observed, even in subsequent experiments when HOCs + DOM mixtures were preincubated for six days before exposure to H4IIE-luc. Thus, DOM does not seem to protect organisms against AhR-mediated toxic effects of HOCs (as predicted due to sorption of HOCs on DOM), but it can enhance their potency for AhR-mediated effects in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environment International

ISSN

0160-4120

e-ISSN

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Svazek periodika

37

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

960-964

Kód UT WoS článku

000292012100017

EID výsledku v databázi Scopus

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