Synthesis of new heretocyclic compounds via two regioisomeric esters with tetrahydrobenzo[b]thiophene scaffolding

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of new heretocyclic compounds via two regioisomeric esters with tetrahydrobenzo[b]thiophene scaffolding

Popis výsledku v původním jazyce

We report herein a synthesis of two regioisomeric aldehydes with tetrahydrobenzo[b]thiophene skeleton and partially protected allylamino group in ortho position on the thiophene ring. We used them for reaction with five substituted secondary amines undersolvent free conditions and conventional heating to in situ formation of azomethine ylides intramolecularly reacting to fused heterocycles. Cyclohexanone was the starting material for both pathways leading to substituted regioisomeric compounds. While asynthesis of first compound was based on literature pattern, a new synthetic protocol for preparation of second compound had to be developed.

Název v anglickém jazyce

Synthesis of new heretocyclic compounds via two regioisomeric esters with tetrahydrobenzo[b]thiophene scaffolding

Popis výsledku anglicky

We report herein a synthesis of two regioisomeric aldehydes with tetrahydrobenzo[b]thiophene skeleton and partially protected allylamino group in ortho position on the thiophene ring. We used them for reaction with five substituted secondary amines undersolvent free conditions and conventional heating to in situ formation of azomethine ylides intramolecularly reacting to fused heterocycles. Cyclohexanone was the starting material for both pathways leading to substituted regioisomeric compounds. While asynthesis of first compound was based on literature pattern, a new synthetic protocol for preparation of second compound had to be developed.

Druh

O - Ostatní výsledky

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů