Structural insight into binding variability of Aspergillus fumigatus lectin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00057542" target="_blank" >RIV/00216224:14310/12:00057542 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Structural insight into binding variability of Aspergillus fumigatus lectin

Popis výsledku v původním jazyce

We have identified one lectin that is present on conidia surface of A. fumigatus and thus can be involved in host tissue binding. The binding experiments clearly showed presence of more than one type of binding sites. By preparing protein crystals and solving the 3D structure by X-ray diffraction, we were able to identify six binding sites per monomer. The more complex analysis of structures with different ligands distinguished different binding pattern of each binding site that results in variable specificity and can be correlated with other experimental data.

Název v anglickém jazyce

Structural insight into binding variability of Aspergillus fumigatus lectin

Popis výsledku anglicky

We have identified one lectin that is present on conidia surface of A. fumigatus and thus can be involved in host tissue binding. The binding experiments clearly showed presence of more than one type of binding sites. By preparing protein crystals and solving the 3D structure by X-ray diffraction, we were able to identify six binding sites per monomer. The more complex analysis of structures with different ligands distinguished different binding pattern of each binding site that results in variable specificity and can be correlated with other experimental data.

Druh

O - Ostatní výsledky

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA303%2F09%2F1168" target="_blank" >GA303/09/1168: Lektiny z lidských patogenů - struktura, funkce, inženýrství</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů