Expression of mycobacterial Rv3782 galactofuranosyltransferase in fussion with MBP

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00060443" target="_blank" >RIV/00216224:14310/12:00060443 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression of mycobacterial Rv3782 galactofuranosyltransferase in fussion with MBP

Popis výsledku v původním jazyce

Mycobacterium tuberculosis is a gram positive, acid resistent bacterium causing chronic illness. Tuberculosis is characterized by a disease persistence and overall difficulties associated with its treatment. A combination of the sophisticated defence barrier and the slow metabolism of the bacterium make it a difficult target for therapeutics. The mycobacterial cell wall is an essential, covalently linked complex of highly hydrophobic mycolic acids, peptidoglycan and heteropolymeric arabinogalactan. Arabinogalactan is composed of about 30 alternating 5- and 6-linked b-D-galactofuranose (Galf) units. It anchores in peptidoglycan by a dedicated linker unit, a-L-rhamnopyranosyl-(1-3)-N-acetyl-a-D-glucosaminyl-phosphate [Rha-(1-3)-GlcNAc-P]. Two to three arabinan chains containing approximately 23 D-arabinofuranose (Araf) units each, composed mostly of 5-linked a-D-Araf with branching introduced by 3,5-a-D-Araf, are bound to the galactan.

Název v anglickém jazyce

Expression of mycobacterial Rv3782 galactofuranosyltransferase in fussion with MBP

Popis výsledku anglicky

Mycobacterium tuberculosis is a gram positive, acid resistent bacterium causing chronic illness. Tuberculosis is characterized by a disease persistence and overall difficulties associated with its treatment. A combination of the sophisticated defence barrier and the slow metabolism of the bacterium make it a difficult target for therapeutics. The mycobacterial cell wall is an essential, covalently linked complex of highly hydrophobic mycolic acids, peptidoglycan and heteropolymeric arabinogalactan. Arabinogalactan is composed of about 30 alternating 5- and 6-linked b-D-galactofuranose (Galf) units. It anchores in peptidoglycan by a dedicated linker unit, a-L-rhamnopyranosyl-(1-3)-N-acetyl-a-D-glucosaminyl-phosphate [Rha-(1-3)-GlcNAc-P]. Two to three arabinan chains containing approximately 23 D-arabinofuranose (Araf) units each, composed mostly of 5-linked a-D-Araf with branching introduced by 3,5-a-D-Araf, are bound to the galactan.

Druh

O - Ostatní výsledky

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů